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Chlorphenesin Side Effects

The most commonly reported side effects of chlorphenesin include toxic epidermal necrolysis, rash, and pallor, based on 53 FDA adverse event reports from 2004 to 2025.

Chlorphenesin side effects

Percentages show how often each reaction appears relative to total reports for chlorphenesin.

1
Toxic Epidermal Necrolysis15.1%8
2
Rash11.3%6
3
Pallor9.4%5
4
Drug Interaction7.5%4
5
Fall7.5%4
6
Diarrhoea7.5%4
7
Dizziness5.7%3
8
Pyrexia5.7%3
9
Nausea5.7%3
10
Palpitations3.8%2
11
Nausea3.8%2
12
Hypertension3.8%2
13
Gait Disturbance3.8%2
14
Somnolence3.8%2
15
Malaise3.8%2

These are voluntary reports and do not establish that chlorphenesin caused these reactions.

Report severity

98.1%Serious52 reports
67.9%Hospitalizations36 reports
22.6%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Chlorphenesin drug interactions

Other drugs that appear in adverse event reports alongside chlorphenesin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen17.0%9
2
Filgrastim15.1%8
3
Ganciclovir15.1%8
4
Vancomycin15.1%8
5
Amphotericin-b15.1%8
6
Caspofungin-acetate15.1%8
7
Enoxaparin-sodium15.1%8
8
Meropenem15.1%8
9
Ondansetron15.1%8
10
Diclofenac5.7%3
11
Sulfamethoxazole5.7%3
12
Acyclovir5.7%3
13
Celecoxib5.7%3
14
Dextromethorphan5.7%3
15
Methotrexate3.8%2

Taken alongside

1
Amlodipine26.4%14
2
Folic-acid18.9%10
3
Metoclopramide-hydrochloride18.9%10
4
Mycophenolate17.0%9
5
Nystatin17.0%9
6
Prednisolone17.0%9
7
Ranitidine17.0%9
8
Cyclosporine15.1%8
9
Pantoprazole-sodium15.1%8
10
Cholecalciferol13.2%7
11
Pimozide13.2%7
12
Furosemide9.4%5
13
Hydrocortisone9.4%5
14
Deoxycholic-acid9.4%5
15
Valsartan7.5%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports chlorphenesin side effects

49.1% of chlorphenesin adverse event reports involve female patients and 49.1% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.1%
Male49.1%
Unknown1.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6457.4%
65+42.6%

What is chlorphenesin used for

Conditions and purposes for which patients were taking chlorphenesin when the adverse event was reported.

Analgesic TherapyBack PainConvulsionMuscle SpasmsOedema PeripheralOsteoarthritisOsteoarthritisPainPain In ExtremityProcedural PainProduct Used For Unknown IndicationProduct Used For Unknown IndicationSpinal Osteoarthritis

Chlorphenesin brand names and reporting trend

Chlorphenesin is sold under the brand name Maolate.

Brand names

Maolate58

Quarterly reports (20042025)

200420102025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking chlorphenesin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.