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Chloroprocaine Side Effects

The most commonly reported side effects of chloroprocaine include anaesthetic complication, maternal exposure during pregnancy, and maternal exposure during delivery, based on 161 FDA adverse event reports from 2004 to 2025. 6.2% of reports found the drug to be ineffective.

Chloroprocaine side effects

Percentages show how often each reaction appears relative to total reports for chloroprocaine.

1
Anaesthetic Complication7.5%12
2
Drug Ineffective6.2%10
3
Maternal Exposure During Pregnancy5.6%9
4
Drug Ineffective4.3%7
5
Maternal Exposure During Delivery4.3%7
6
Dyspnoea4.3%7
7
Off Label Use4.3%7
8
Blood Pressure Decreased4.3%7
9
Eye Pain4.3%7
10
Product Temperature Excursion Issue4.3%7
11
Cardiac Arrest3.7%6
12
Toxicity To Various Agents3.7%6
13
Nausea3.7%6
14
Exposure During Pregnancy3.7%6
15
Hypotension3.1%5

These are voluntary reports and do not establish that chloroprocaine caused these reactions.

Report severity

68.9%Serious111 reports
31.1%Hospitalizations50 reports
6.8%Fatal11 reports

Seriousness is determined by the reporter, not by OpenClaim.

Chloroprocaine drug interactions

Other drugs that appear in adverse event reports alongside chloroprocaine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lidocaine12.4%20
2
Bupivacaine12.4%20
3
Fentanyl11.2%18
4
Ropivacaine-hydrochloride7.5%12
5
Dexamethasone5.0%8
6
Oxytocin5.0%8
7
Treprostinil4.3%7
8
Epoprostenol-sodium3.7%6
9
Acetaminophen3.7%6
10
Esomeprazole3.1%5
11
Epinephrine3.1%5
12
Sildenafil-citrate3.1%5
13
Betamethasone3.1%5
14
Azacitidine3.1%5
15
Venetoclax3.1%5

Taken alongside

1
Acetaminophen8.1%13
2
Fentanyl6.8%11
3
Epinephrine6.8%11
4
Dexamethasone6.2%10
5
Midazolam6.2%10
6
Propofol5.6%9
7
Pantoprazole-sodium5.6%9
8
Tramadol-hydrochloride5.0%8
9
Bupivacaine4.3%7
10
Albuterol4.3%7
11
Oxytocin4.3%7
12
Metoprolol3.7%6
13
Granisetron3.7%6
14
Lorazepam3.7%6
15
Apomorphine-hydrochloride3.7%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports chloroprocaine side effects

55.9% of chloroprocaine adverse event reports involve female patients and 26.1% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.9%
Male26.1%
Unknown18.0%

Age group

< 29.6%
2–111.7%
12–172.6%
18–6456.5%
65+29.6%

What is chloroprocaine used for

Conditions and purposes for which patients were taking chloroprocaine when the adverse event was reported.

Abortion InducedAnaesthesiaAnalgesic TherapyAnkle FractureArthroscopyAnaesthesiaArthralgiaBack PainCaesarean SectionCatheter PlacementCentral Venous CatheterisationChronic Obstructive Pulmonary DiseaseCaesarean SectionCataract OperationEpidural Anaesthesia

Showing 15 of 43 indications

Chloroprocaine brand names and reporting trend

Chloroprocaine is sold under the brand name Chloroprocaine Hydrochloride.

Brand names

Chloroprocaine Hydrochloride36

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking chloroprocaine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.