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Chenodiol Side Effects

The most commonly reported side effects of chenodiol include dehydration, off label use, and varicella zoster virus infection, based on 41 FDA adverse event reports from 2010 to 2025. 7.3% of reports found the drug to be ineffective.

Chenodiol side effects

Percentages show how often each reaction appears relative to total reports for chenodiol.

1
Dehydration12.2%5
2
Off Label Use12.2%5
3
Varicella Zoster Virus Infection9.8%4
4
Herpes Zoster Disseminated9.8%4
5
Respiratory Failure9.8%4
6
Multiple Organ Dysfunction Syndrome9.8%4
7
Retinitis9.8%4
8
Optic Neuritis9.8%4
9
Staphylococcal Skin Infection9.8%4
10
Staphylococcal Scalded Skin Syndrome9.8%4
11
Human Bocavirus Infection9.8%4
12
Gastroenteritis Viral9.8%4
13
Adenovirus Infection9.8%4
14
Vanishing Bile Duct Syndrome9.8%4
15
Lymphopenia9.8%4

These are voluntary reports and do not establish that chenodiol caused these reactions.

Report severity

48.8%Serious20 reports
29.3%Hospitalizations12 reports
17.1%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Chenodiol drug interactions

Other drugs that appear in adverse event reports alongside chenodiol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Basiliximab9.8%4
2
Prednisone9.8%4
3
Fludarabine-phosphate9.8%4
4
Cyclophosphamide9.8%4
5
Tacrolimus9.8%4
6
Melphalan9.8%4
7
Alemtuzumab9.8%4
8
Treosulfan9.8%4
9
Simvastatin7.3%3
10
Carbidopa7.3%3
11
Levodopa7.3%3
12
Primidone4.9%2
13
Amantadine4.9%2
14
Topiramate4.9%2
15
Mycophenolate4.9%2

Taken alongside

1
Polymyxin-b-sulfate9.8%4
2
Amphotericin-b9.8%4
3
Pentamidine-isethionate9.8%4
4
Defibrotide-sodium9.8%4
5
Acyclovir9.8%4
6
Ursodiol9.8%4
7
Neomycin-sulfate9.8%4
8
Prednisone7.3%3
9
Mycophenolate7.3%3
10
Aripiprazole4.9%2
11
Propranolol-hydrochloride4.9%2
12
Fludarabine-phosphate4.9%2
13
Cyclophosphamide4.9%2
14
Alemtuzumab4.9%2
15
Treosulfan4.9%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports chenodiol side effects

46.3% of chenodiol adverse event reports involve female patients and 51.2% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.3%
Male51.2%
Unknown2.4%

Age group

< 20.0%
2–1115.6%
12–170.0%
18–6481.3%
65+3.1%

What is chenodiol used for

Conditions and purposes for which patients were taking chenodiol when the adverse event was reported.

CholelithiasisCerebrotendinous XanthomatosisCholelithiasis ObstructiveDrug TherapyHypercholesterolaemiaLipid Metabolism DisorderLipidosisLipids AbnormalLipid Metabolism DisorderLipidosisProduct Used For Unknown IndicationXanthomatosisXanthomatosis

Chenodiol brand names and reporting trend

Chenodiol is sold under the brand name Chenix.

Brand names

Chenix43

Quarterly reports (20102025)

2010201620202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking chenodiol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.