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Ceritinib Side Effects

The most commonly reported side effects of ceritinib include malignant neoplasm progression, diarrhoea, and nausea, based on 2,367 FDA adverse event reports from 2014 to 2025. 3.5% of reports found the drug to be ineffective.

Ceritinib side effects

Percentages show how often each reaction appears relative to total reports for ceritinib.

1
Malignant Neoplasm Progression18.0%425
2
Diarrhoea17.9%423
3
Nausea14.3%339
4
Death11.7%278
5
Vomiting9.4%222
6
Metastases To Central Nervous System7.2%171
7
Fatigue5.6%132
8
Non-small Cell Lung Cancer5.4%129
9
Decreased Appetite4.9%116
10
Disease Progression4.6%110
11
Abdominal Pain4.1%98
12
Dyspnoea4.1%98
13
Non-small Cell Lung Cancer Stage Iv3.8%90
14
Asthenia3.8%89
15
Drug Ineffective3.5%84

These are voluntary reports and do not establish that ceritinib caused these reactions.

Report severity

81.3%Serious1,924 reports
24.6%Hospitalizations583 reports
23.2%Fatal549 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ceritinib drug interactions

Other drugs that appear in adverse event reports alongside ceritinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Crizotinib9.0%214
2
Alectinib-hydrochloride6.3%149
3
Pemetrexed3.5%84
4
Lorlatinib2.8%66
5
Carboplatin2.7%64
6
Brigatinib2.3%54
7
Bevacizumab1.7%41
8
Cisplatin1.1%25
9
Paclitaxel1.0%24
10
Gemcitabine0.9%21
11
Nivolumab0.8%20
12
Docetaxel0.8%19
13
Levetiracetam0.7%17
14
Zoledronic-acid0.7%16
15
Dexamethasone0.6%14

Taken alongside

1
Ondansetron3.9%93
2
Acetaminophen3.1%73
3
Oxycodone2.4%56
4
Omeprazole2.2%52
5
Crizotinib2.2%51
6
Dexamethasone2.1%49
7
Levothyroxine-sodium1.9%45
8
Pantoprazole-sodium1.9%45
9
Prochlorperazine1.7%40
10
Lorazepam1.5%35
11
Ergocalciferol1.5%35
12
Calcium1.4%32
13
Loperamide-hydrochloride1.4%32
14
Furosemide1.3%31
15
Folic-acid1.3%30

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ceritinib side effects

46.3% of ceritinib adverse event reports involve female patients and 38.4% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.3%
Male38.4%
Unknown15.2%

Age group

< 20.5%
2–111.5%
12–171.1%
18–6465.4%
65+31.5%

What is ceritinib used for

Conditions and purposes for which patients were taking ceritinib when the adverse event was reported.

Accidental Exposure To ProductAdenocarcinomaAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdrenal Gland CancerAgranulocytosisAir EmbolismAlk Gene Rearrangement PositiveAlk Gene Rearrangement PositiveAnaplastic Large-cell LymphomaAnaplastic Lymphoma Kinase Gene MutationArthritis BacterialAdenocarcinomaAdrenal Gland CancerAnaplastic Large Cell Lymphoma T- And Null-cell Types

Showing 15 of 155 indications

Ceritinib brand names and reporting trend

Ceritinib is sold under the brand name Zykadia.

Brand names

Zykadia801

Quarterly reports (20142025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ceritinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.