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Cenobamate Side Effects

The most commonly reported side effects of cenobamate include seizure, product dose omission issue, and fatigue, based on 6,462 FDA adverse event reports from 2020 to 2025. 4.4% of reports found the drug to be ineffective.

Cenobamate side effects

Percentages show how often each reaction appears relative to total reports for cenobamate.

1
Seizure28.1%1,816
2
Product Dose Omission Issue19.5%1,263
3
Fatigue10.4%672
4
Somnolence10.2%661
5
Dizziness8.3%537
6
Off Label Use7.6%494
7
Product Use Issue6.0%386
8
Fall5.7%368
9
Headache4.9%317
10
Drug Interaction4.8%311
11
Drug Ineffective4.4%284
12
Wrong Technique In Product Usage Process4.3%277
13
Feeling Abnormal3.8%245
14
Gait Disturbance3.7%242
15
Balance Disorder3.4%219

These are voluntary reports and do not establish that cenobamate caused these reactions.

Report severity

39.7%Serious2,566 reports
20.1%Hospitalizations1,301 reports
2.4%Fatal156 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cenobamate drug interactions

Other drugs that appear in adverse event reports alongside cenobamate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lacosamide7.7%499
2
Levetiracetam7.1%456
3
Clobazam5.9%380
4
Lamotrigine5.0%322
5
Brivaracetam4.2%272
6
Cannabidiol3.6%230
7
Perampanel3.1%203
8
Zonisamide2.7%173
9
Carbamazepine2.6%166
10
Oxcarbazepine2.5%162
11
Topiramate2.3%149
12
Phenytoin2.2%141
13
Valproate-sodium2.0%131
14
Clonazepam1.6%103
15
Phenobarbital-sodium1.5%96

Taken alongside

1
Levetiracetam12.2%789
2
Lamotrigine11.0%712
3
Lacosamide10.5%678
4
Clobazam8.6%554
5
Brivaracetam5.5%358
6
Clonazepam5.1%332
7
Topiramate4.6%300
8
Zonisamide4.5%292
9
Ergocalciferol4.5%289
10
Divalproex-sodium3.9%255
11
Oxcarbazepine3.9%251
12
Carbamazepine3.4%222
13
Lorazepam3.2%208
14
Perampanel3.2%206
15
Levothyroxine-sodium3.0%194

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cenobamate side effects

8.6% of cenobamate adverse event reports involve female patients and 7.2% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female8.6%
Male7.2%
Unknown84.2%

Age group

< 20.9%
2–115.3%
12–175.3%
18–6481.1%
65+7.4%

What is cenobamate used for

Conditions and purposes for which patients were taking cenobamate when the adverse event was reported.

Atonic SeizuresAuraAdjuvant TherapyAffect LabilityAnticonvulsant Drug LevelAtonic SeizuresAuraAutoimmune DisorderBrain InjuryBrain NeoplasmBehaviour DisorderBrain NeoplasmCdkl5 Deficiency DisorderCerebral PalsyCognitive Disorder

Showing 15 of 122 indications

Cenobamate brand names and reporting trend

Cenobamate is sold under the brand name Cenobamate.

Brand names

Cenobamate1,091

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cenobamate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.