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Celecoxib Side Effects

The most commonly reported side effects of celecoxib include pain, arthralgia, and fatigue, based on 134,307 FDA adverse event reports from 2004 to 2025. 11.8% of reports found the drug to be ineffective.

Celecoxib side effects

Percentages show how often each reaction appears relative to total reports for celecoxib.

1
Drug Ineffective11.8%15,851
2
Pain7.8%10,543
3
Arthralgia7.2%9,736
4
Fatigue6.5%8,664
5
Nausea5.9%7,965
6
Off Label Use5.8%7,780
7
Drug Hypersensitivity5.5%7,445
8
Rheumatoid Arthritis5.1%6,874
9
Diarrhoea4.8%6,461
10
Headache4.6%6,180
11
Myocardial Infarction4.5%6,009
12
Condition Aggravated4.2%5,687
13
Malaise4.2%5,680
14
Rash4.0%5,426
15
Pain In Extremity3.9%5,258

These are voluntary reports and do not establish that celecoxib caused these reactions.

Report severity

71.1%Serious95,504 reports
31.3%Hospitalizations42,085 reports
9.4%Fatal12,609 reports

Seriousness is determined by the reporter, not by OpenClaim.

Celecoxib drug interactions

Other drugs that appear in adverse event reports alongside celecoxib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab11.0%14,767
2
Methotrexate9.9%13,265
3
Etanercept9.9%13,230
4
Abatacept6.5%8,734
5
Tocilizumab6.4%8,583
6
Leflunomide6.2%8,353
7
Infliximab6.1%8,183
8
Hydroxychloroquine-sulfate5.5%7,378
9
Rituximab5.5%7,321
10
Tofacitinib5.4%7,287
11
Diclofenac5.4%7,249
12
Prednisone5.1%6,889
13
Secukinumab5.1%6,852
14
Sulfasalazine5.0%6,738
15
Naproxen4.8%6,510

Taken alongside

1
Acetaminophen14.7%19,716
2
Prednisone9.6%12,954
3
Ergocalciferol9.4%12,676
4
Levothyroxine-sodium8.8%11,871
5
Aspirin8.8%11,855
6
Methotrexate8.5%11,440
7
Folic-acid8.0%10,691
8
Omeprazole7.8%10,518
9
Gabapentin7.2%9,619
10
Atorvastatin-calcium6.5%8,663
11
Pantoprazole-sodium6.0%8,015
12
Ibuprofen6.0%8,007
13
Lisinopril5.8%7,734
14
Amlodipine5.7%7,688
15
Calcium5.5%7,370

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports celecoxib side effects

64.5% of celecoxib adverse event reports involve female patients and 27.7% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female64.5%
Male27.7%
Unknown7.8%

Age group

< 20.1%
2–110.6%
12–170.7%
18–6458.0%
65+40.5%

What is celecoxib used for

Conditions and purposes for which patients were taking celecoxib when the adverse event was reported.

AbasiaAbdominal DiscomfortAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal SymptomAbortionAbscess LimbAccidentAccident At WorkAcneAcoustic NeuromaAcral Lentiginous MelanomaAcute Lymphocytic Leukaemia RecurrentAcute Myocardial Infarction

Showing 15 of 1,641 indications

Celecoxib brand names and reporting trend

Celecoxib is sold under the brand name Elyxyb.

Brand names

Elyxyb49,911

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking celecoxib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.