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Ceftriaxone Side Effects

The most commonly reported side effects of ceftriaxone include off label use, pyrexia, and acute kidney injury, based on 49,207 FDA adverse event reports from 2004 to 2025. 7.0% of reports found the drug to be ineffective.

Ceftriaxone side effects

Percentages show how often each reaction appears relative to total reports for ceftriaxone.

1
Off Label Use8.1%3,984
2
Drug Ineffective7.0%3,469
3
Pyrexia4.6%2,282
4
Acute Kidney Injury4.4%2,162
5
Dyspnoea3.4%1,681
6
Condition Aggravated3.2%1,566
7
Pneumonia3.1%1,547
8
Nausea2.8%1,381
9
Vomiting2.7%1,327
10
Diarrhoea2.6%1,280
11
Drug Reaction With Eosinophilia And Systemic Symptoms2.6%1,259
12
Rash2.5%1,222
13
Drug Interaction2.4%1,175
14
Sepsis2.3%1,118
15
Anaemia2.2%1,079

These are voluntary reports and do not establish that ceftriaxone caused these reactions.

Report severity

93.6%Serious46,080 reports
55.6%Hospitalizations27,383 reports
17.4%Fatal8,557 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ceftriaxone drug interactions

Other drugs that appear in adverse event reports alongside ceftriaxone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Vancomycin8.6%4,237
2
Metronidazole7.2%3,547
3
Azithromycin7.1%3,512
4
Dexamethasone4.3%2,118
5
Acetaminophen4.1%2,030
6
Amoxicillin4.1%2,002
7
Methylprednisolone3.7%1,804
8
Prednisone3.2%1,572
9
Meropenem3.2%1,557
10
Hydroxychloroquine-sulfate3.1%1,516
11
Ciprofloxacin2.9%1,442
12
Levofloxacin2.9%1,412
13
Enoxaparin-sodium2.8%1,356
14
Remdesivir2.7%1,335
15
Furosemide2.5%1,249

Taken alongside

1
Acetaminophen12.7%6,239
2
Furosemide9.2%4,522
3
Vancomycin8.1%4,003
4
Azithromycin7.4%3,659
5
Pantoprazole-sodium6.5%3,222
6
Aspirin6.5%3,203
7
Dexamethasone6.0%2,946
8
Enoxaparin-sodium5.8%2,834
9
Metronidazole5.6%2,771
10
Prednisone5.1%2,492
11
Omeprazole5.0%2,479
12
Albuterol5.0%2,443
13
Ondansetron4.9%2,406
14
Methylprednisolone4.9%2,387
15
Insulin4.8%2,385

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ceftriaxone side effects

44.4% of ceftriaxone adverse event reports involve female patients and 47.3% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.4%
Male47.3%
Unknown8.3%

Age group

< 23.2%
2–115.9%
12–172.7%
18–6447.0%
65+41.1%

What is ceftriaxone used for

Conditions and purposes for which patients were taking ceftriaxone when the adverse event was reported.

Abdominal AbscessAbdominal DistensionAbdominal InfectionAbdominal InjuryAbdominal PainAbdominal Pain LowerAbdominal SepsisAbscessAbscess DrainageAbscess IntestinalAbscess LimbAbscess ManagementAbscess NeckAcinetobacter InfectionAcne

Showing 15 of 2,245 indications

Ceftriaxone brand names and reporting trend

Ceftriaxone is sold under the brand name Ceftriaxone Sodium.

Brand names

Ceftriaxone Sodium8,142

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ceftriaxone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.