OpenClaim

Ceftolozane Side Effects

The most commonly reported side effects of ceftolozane include off label use, product use in unapproved indication, and no adverse event, based on 1,047 FDA adverse event reports from 2015 to 2025. 4.9% of reports found the drug to be ineffective.

Ceftolozane side effects

Percentages show how often each reaction appears relative to total reports for ceftolozane.

1
Off Label Use14.5%152
2
Product Use In Unapproved Indication12.6%132
3
No Adverse Event8.4%88
4
Death8.3%87
5
Product Use Issue6.4%67
6
Pathogen Resistance5.4%57
7
Drug Ineffective4.9%51
8
Acute Kidney Injury3.7%39
9
Drug Resistance3.4%36
10
Pneumonia2.7%28
11
Thrombocytopenia2.7%28
12
Pancytopenia2.7%28
13
Overdose2.6%27
14
Incorrect Dose Administered2.5%26
15
Renal Failure2.5%26

These are voluntary reports and do not establish that ceftolozane caused these reactions.

Report severity

69.9%Serious732 reports
28.9%Hospitalizations303 reports
23.6%Fatal247 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ceftolozane drug interactions

Other drugs that appear in adverse event reports alongside ceftolozane. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tazobactam-sodium83.9%878
2
Vancomycin4.3%45
3
Linezolid4.2%44
4
Mycophenolate3.9%41
5
Amikacin-sulfate3.3%35
6
Tobramycin3.2%34
7
Meropenem3.2%34
8
Cyclosporine3.2%34
9
Acetaminophen3.0%31
10
Methylprednisolone2.9%30
11
Sulfamethoxazole2.8%29
12
Voriconazole2.8%29
13
Caspofungin-acetate2.7%28
14
Daptomycin2.6%27
15
Trimethoprim2.5%26

Taken alongside

1
Tazobactam-sodium9.1%95
2
Meropenem6.0%63
3
Vancomycin5.2%54
4
Furosemide4.3%45
5
Insulin4.0%42
6
Amlodipine4.0%42
7
Colistin-sulfate3.5%37
8
Prednisone3.5%37
9
Linezolid3.4%36
10
Acetaminophen3.4%36
11
Tobramycin3.3%35
12
Ciprofloxacin3.3%35
13
Piperacillin3.2%33
14
Methylprednisolone3.1%32
15
Bisoprolol-fumarate3.1%32

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ceftolozane side effects

31.3% of ceftolozane adverse event reports involve female patients and 47.7% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female31.3%
Male47.7%
Unknown21.0%

Age group

< 20.8%
2–112.0%
12–173.3%
18–6449.7%
65+44.3%

What is ceftolozane used for

Conditions and purposes for which patients were taking ceftolozane when the adverse event was reported.

Abdominal AbscessAbdominal InfectionAbdominal Wall AbscessAbscessAcinetobacter InfectionAlcaligenes InfectionAntibiotic TherapyArthritis InfectiveAbdominal AbscessAbdominal InfectionAcinetobacter InfectionActinomycotic Pulmonary InfectionAcute Respiratory Distress SyndromeAllergy TestAnti-infective Therapy

Showing 15 of 191 indications

Ceftolozane brand names and reporting trend

Ceftolozane is sold under the brand name Zerbaxa.

Brand names

Zerbaxa114

Quarterly reports (20152025)

20152016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ceftolozane with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.