OpenClaim

Ceftaroline Side Effects

The most commonly reported side effects of ceftaroline include off label use, acute kidney injury, and neutropenia, based on 1,647 FDA adverse event reports from 2011 to 2025. 12.3% of reports found the drug to be ineffective.

Ceftaroline side effects

Percentages show how often each reaction appears relative to total reports for ceftaroline.

1
Off Label Use16.2%267
2
Drug Ineffective12.3%203
3
Acute Kidney Injury6.7%111
4
Neutropenia6.1%101
5
Death5.6%93
6
Thrombocytopenia4.2%69
7
Rash3.9%64
8
Treatment Failure3.8%63
9
Product Use In Unapproved Indication3.8%62
10
Pyrexia3.6%59
11
Agranulocytosis2.7%44
12
Condition Aggravated2.6%42
13
Eosinophilia2.5%41
14
Toxic Epidermal Necrolysis2.4%40
15
Nausea2.3%38

These are voluntary reports and do not establish that ceftaroline caused these reactions.

Report severity

84.6%Serious1,394 reports
41.7%Hospitalizations687 reports
20.4%Fatal336 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ceftaroline drug interactions

Other drugs that appear in adverse event reports alongside ceftaroline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Daptomycin27.0%444
2
Vancomycin19.9%328
3
Linezolid7.8%129
4
Doxycycline4.3%71
5
Levofloxacin3.2%53
6
Meropenem3.0%49
7
Tigecycline2.8%46
8
Azithromycin2.7%44
9
Rifampin2.6%42
10
Hydroxychloroquine-sulfate2.4%39
11
Metronidazole2.2%37
12
Clindamycin2.1%35
13
Ceftriaxone-sodium2.0%33
14
Methylprednisolone2.0%33
15
Gentamicin-sulfate2.0%33

Taken alongside

1
Vancomycin8.1%133
2
Daptomycin7.8%129
3
Acetaminophen6.3%104
4
Furosemide5.0%83
5
Enoxaparin-sodium4.4%73
6
Meropenem4.2%69
7
Linezolid3.7%61
8
Omeprazole3.6%59
9
Insulin3.5%57
10
Albuterol3.4%56
11
Aspirin3.3%54
12
Ondansetron3.2%52
13
Metoprolol3.1%51
14
Pantoprazole-sodium3.1%51
15
Metronidazole3.0%50

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ceftaroline side effects

31.5% of ceftaroline adverse event reports involve female patients and 50.3% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female31.5%
Male50.3%
Unknown18.2%

Age group

< 21.5%
2–111.4%
12–172.0%
18–6457.1%
65+38.0%

What is ceftaroline used for

Conditions and purposes for which patients were taking ceftaroline when the adverse event was reported.

AbscessAbscess LimbAcute Kidney InjuryAdverse EventAnti-infective TherapyAntibiotic Level Above TherapeuticAntibiotic ProphylaxisAntibiotic TherapyArthritisArthritis BacterialArthritis InfectiveAbdominal AbscessAbscess LimbAcute Kidney InjuryAntibiotic Prophylaxis

Showing 15 of 259 indications

Ceftaroline brand names and reporting trend

Ceftaroline is sold under the brand name Ceftaroline Fosamil.

Brand names

Ceftaroline Fosamil1,859

Quarterly reports (20112025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ceftaroline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.