OpenClaim

Cefpodoxime Side Effects

The most commonly reported side effects of cefpodoxime include pneumonia, fatigue, and diarrhoea, based on 3,020 FDA adverse event reports from 2004 to 2025. 2.9% of reports found the drug to be ineffective.

Cefpodoxime side effects

Percentages show how often each reaction appears relative to total reports for cefpodoxime.

1
Pneumonia6.5%195
2
Fatigue5.1%154
3
Diarrhoea5.0%150
4
Pyrexia4.9%149
5
Nausea4.7%143
6
Acute Kidney Injury3.9%117
7
Off Label Use3.7%113
8
Dyspnoea3.7%112
9
Urinary Tract Infection3.5%106
10
Death3.4%102
11
Dizziness3.0%91
12
Drug Ineffective2.9%89
13
Vomiting2.9%87
14
Headache2.6%79
15
Pain2.6%78

These are voluntary reports and do not establish that cefpodoxime caused these reactions.

Report severity

84.7%Serious2,558 reports
57.5%Hospitalizations1,735 reports
12.0%Fatal361 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cefpodoxime drug interactions

Other drugs that appear in adverse event reports alongside cefpodoxime. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide4.5%136
2
Ibuprofen4.2%128
3
Venetoclax3.2%96
4
Acetaminophen3.1%93
5
Pantoprazole-sodium3.0%92
6
Ciprofloxacin3.0%91
7
Azithromycin2.8%85
8
Amoxicillin2.7%83
9
Prednisone2.5%75
10
Dexamethasone2.3%68
11
Prednisolone2.1%63
12
Ceftriaxone-sodium2.0%61
13
Metronidazole1.9%56
14
Doxycycline1.7%52
15
Levofloxacin1.7%52

Taken alongside

1
Acetaminophen17.2%518
2
Furosemide12.3%372
3
Aspirin11.9%358
4
Prednisone11.7%354
5
Albuterol11.6%350
6
Ondansetron11.0%331
7
Pantoprazole-sodium10.6%320
8
Acyclovir10.4%314
9
Ergocalciferol10.0%302
10
Metoprolol9.2%279
11
Levothyroxine-sodium9.2%278
12
Omeprazole8.8%267
13
Amlodipine8.8%267
14
Atorvastatin-calcium8.7%263
15
Dexamethasone7.9%238

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cefpodoxime side effects

51.7% of cefpodoxime adverse event reports involve female patients and 40.2% involve male patients. The largest age group is adult at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.7%
Male40.2%
Unknown8.1%

Age group

< 21.8%
2–115.0%
12–172.5%
18–6448.4%
65+42.2%

What is cefpodoxime used for

Conditions and purposes for which patients were taking cefpodoxime when the adverse event was reported.

Abdominal PainAcute Hiv InfectionAcute SinusitisAdverse EventAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyArthralgiaAscitesAstheniaAcute Febrile Neutrophilic DermatosisAdverse EventAlcaligenes InfectionAllergy TestAnal Abscess

Showing 15 of 287 indications

Cefpodoxime brand names and reporting trend

Cefpodoxime is sold under the brand name Cefpodoxime Proxetil.

Brand names

Cefpodoxime Proxetil2,467

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cefpodoxime with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.