OpenClaim

Cefoperazone Side Effects

The most commonly reported side effects of cefoperazone include off label use, pyrexia, and pneumonia, based on 769 FDA adverse event reports from 2004 to 2025. 6.0% of reports found the drug to be ineffective.

Cefoperazone side effects

Percentages show how often each reaction appears relative to total reports for cefoperazone.

1
Off Label Use6.6%51
2
Drug Ineffective6.0%46
3
Pyrexia4.7%36
4
Pneumonia4.6%35
5
Pruritus3.3%25
6
Anaphylactic Shock3.0%23
7
Dyspnoea2.9%22
8
Drug Hypersensitivity2.9%22
9
Rash2.7%21
10
Multiple Organ Dysfunction Syndrome2.7%21
11
Product Use In Unapproved Indication2.7%21
12
White Blood Cell Count Decreased2.5%19
13
Platelet Count Decreased2.2%17
14
Respiratory Failure2.1%16
15
Anaemia2.1%16

These are voluntary reports and do not establish that cefoperazone caused these reactions.

Report severity

97.8%Serious752 reports
38.1%Hospitalizations293 reports
27.4%Fatal211 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cefoperazone drug interactions

Other drugs that appear in adverse event reports alongside cefoperazone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Vancomycin7.2%55
2
Sulbactam-sodium5.9%45
3
Methylprednisolone4.3%33
4
Mycophenolate4.2%32
5
Imipenem4.2%32
6
Meropenem4.2%32
7
Moxifloxacin-hydrochloride3.6%28
8
Tacrolimus3.3%25
9
Dexamethasone3.0%23
10
Azithromycin2.9%22
11
Fluconazole2.9%22
12
Cilastatin-sodium2.9%22
13
Metronidazole2.9%22
14
Prednisone2.7%21
15
Piperacillin2.7%21

Taken alongside

1
Sulbactam-sodium16.8%129
2
Sodium-chloride9.8%75
3
Furosemide7.7%59
4
Meropenem7.2%55
5
Methylprednisolone6.8%52
6
Potassium-chloride6.6%51
7
Dexamethasone6.4%49
8
Omeprazole5.9%45
9
Vancomycin4.7%36
10
Metronidazole4.4%34
11
Voriconazole4.3%33
12
Fluconazole4.2%32
13
Insulin4.0%31
14
Linezolid4.0%31
15
Amlodipine3.8%29

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cefoperazone side effects

39.9% of cefoperazone adverse event reports involve female patients and 50.3% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.9%
Male50.3%
Unknown9.8%

Age group

< 25.8%
2–116.1%
12–173.0%
18–6450.1%
65+35.0%

What is cefoperazone used for

Conditions and purposes for which patients were taking cefoperazone when the adverse event was reported.

Abdominal Pain UpperAbscessAcinetobacter InfectionAcute Myeloid LeukaemiaAcute Respiratory Distress SyndromeAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyAntiinflammatory TherapyAppendicitisAppendicitis NoninfectiveAsthmaAbscessAcinetobacter Test PositiveAdhesion

Showing 15 of 192 indications

Cefoperazone brand names and reporting trend

Cefoperazone is sold under the brand name Cefobid.

Brand names

Cefobid809

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cefoperazone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.