OpenClaim

Cefiderocol Side Effects

The most commonly reported side effects of cefiderocol include death, drug resistance, and off label use, based on 772 FDA adverse event reports from 2020 to 2025. 11.7% of reports found the drug to be ineffective.

#1 Reported: DeathAll side effects ↓Top Co-Medication: MeropenemDrug interactions ↓54% of Reports Are AdultDemographics ↓

Cefiderocol side effects

Percentages show how often each reaction appears relative to total reports for cefiderocol.

1
Death18.4%142
2
Drug Ineffective11.7%90
3
Drug Resistance9.8%76
4
Off Label Use9.2%71
5
Treatment Failure8.2%63
6
Pathogen Resistance5.8%45
7
Pneumonia4.9%38
8
Acute Kidney Injury4.7%36
9
Multiple Organ Dysfunction Syndrome4.1%32
10
Septic Shock4.1%32
11
Sepsis3.8%29
12
No Adverse Event3.5%27
13
Condition Aggravated2.7%21
14
Thrombocytopenia2.6%20
15
Infection2.5%19

These are voluntary reports and do not establish that cefiderocol caused these reactions.

Report severity

90.8%Serious701 reports
24.2%Hospitalizations187 reports
52.3%Fatal404 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cefiderocol drug interactions

Other drugs that appear in adverse event reports alongside cefiderocol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Meropenem9.5%73
2
Vancomycin7.9%61
3
Colistin-sulfate7.6%59
4
Linezolid6.1%47
5
Tigecycline4.1%32
6
Amikacin-sulfate3.9%30
7
Tobramycin3.6%28
8
Cefepime-hydrochloride3.5%27
9
Ciprofloxacin3.2%25
10
Polymyxin-b-sulfate3.1%24
11
Levofloxacin3.1%24
12
Doxycycline3.1%24
13
Minocycline-hydrochloride3.0%23
14
Cyclosporine2.8%22
15
Daptomycin2.7%21

Taken alongside

1
Meropenem14.1%109
2
Vancomycin13.0%100
3
Furosemide6.9%53
4
Amikacin-sulfate6.6%51
5
Metronidazole6.5%50
6
Micafungin-sodium5.8%45
7
Cefepime-hydrochloride5.8%45
8
Levofloxacin5.4%42
9
Colistin-sulfate5.3%41
10
Fentanyl4.7%36
11
Tigecycline4.4%34
12
Minocycline-hydrochloride4.3%33
13
Midazolam4.1%32
14
Norepinephrine-bitartrate4.1%32
15
Methylprednisolone4.1%32

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cefiderocol side effects

31.6% of cefiderocol adverse event reports involve female patients and 49.7% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female31.6%
Male49.7%
Unknown18.7%

Age group

< 21.1%
2–112.3%
12–173.4%
18–6453.6%
65+39.6%

What is cefiderocol used for

Conditions and purposes for which patients were taking cefiderocol when the adverse event was reported.

Achromobacter InfectionAcinetobacter BacteraemiaAcinetobacter InfectionAcinetobacter SepsisAntibiotic TherapyAbdominal AbscessAbdominal InfectionAbdominal SepsisAbscess LimbAchromobacter InfectionAcinetobacter BacteraemiaAcinetobacter InfectionAcinetobacter Test PositiveAdverse Drug ReactionAlpha Haemolytic Streptococcal Infection

Showing 15 of 174 indications

Cefiderocol brand names and reporting trend

Cefiderocol is sold under the brand name Fetroja.

Brand names

Fetroja971

Quarterly reports (2020–2025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cefiderocol with another medication?

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