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Caspofungin Side Effects

The most commonly reported side effects of caspofungin include off label use, febrile neutropenia, and pyrexia, based on 9,449 FDA adverse event reports from 2004 to 2025. 16.0% of reports found the drug to be ineffective.

Caspofungin side effects

Percentages show how often each reaction appears relative to total reports for caspofungin.

1
Drug Ineffective16.0%1,508
2
Off Label Use7.7%731
3
Febrile Neutropenia4.1%384
4
Pyrexia3.8%362
5
Multiple Organ Dysfunction Syndrome3.8%358
6
Product Use In Unapproved Indication3.7%346
7
Septic Shock3.5%334
8
Pneumonia3.3%314
9
Acute Kidney Injury3.3%309
10
Sepsis3.0%281
11
Respiratory Failure2.8%268
12
Drug Resistance2.7%256
13
Neutropenia2.7%252
14
Bronchopulmonary Aspergillosis2.6%244
15
Aspergillus Infection2.6%244

These are voluntary reports and do not establish that caspofungin caused these reactions.

Report severity

95.9%Serious9,065 reports
47.4%Hospitalizations4,483 reports
36.6%Fatal3,461 reports

Seriousness is determined by the reporter, not by OpenClaim.

Caspofungin drug interactions

Other drugs that appear in adverse event reports alongside caspofungin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Voriconazole14.5%1,366
2
Amphotericin-b14.2%1,340
3
Meropenem8.9%838
4
Vancomycin8.4%794
5
Mycophenolate7.5%704
6
Tacrolimus7.4%697
7
Cyclophosphamide7.1%672
8
Cytarabine6.8%645
9
Methylprednisolone6.5%614
10
Fluconazole6.3%597
11
Cyclosporine5.6%529
12
Prednisone5.4%506
13
Posaconazole5.0%471
14
Linezolid4.9%466
15
Methotrexate4.7%448

Taken alongside

1
Meropenem14.4%1,356
2
Vancomycin14.1%1,337
3
Amphotericin-b10.1%953
4
Acyclovir9.6%910
5
Voriconazole9.0%854
6
Furosemide8.2%777
7
Acetaminophen8.2%776
8
Fluconazole7.4%698
9
Methylprednisolone7.1%668
10
Sulfamethoxazole7.0%662
11
Pantoprazole-sodium6.7%634
12
Piperacillin6.1%575
13
Ondansetron6.0%569
14
Levofloxacin5.9%555
15
Trimethoprim5.3%499

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports caspofungin side effects

38.2% of caspofungin adverse event reports involve female patients and 53.4% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.2%
Male53.4%
Unknown8.4%

Age group

< 22.8%
2–118.4%
12–177.2%
18–6456.8%
65+24.7%

What is caspofungin used for

Conditions and purposes for which patients were taking caspofungin when the adverse event was reported.

Abdominal AbscessAbdominal InfectionAbdominal SepsisAbscess FungalAcanthamoeba KeratitisAcinetobacter InfectionAcute Generalised Exanthematous PustulosisAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Respiratory Distress SyndromeAdult T-cell Lymphoma/leukaemiaAdverse EventAlpha Haemolytic Streptococcal InfectionAlternaria Infection

Showing 15 of 572 indications

Caspofungin brand names and reporting trend

Caspofungin is sold under the brand name Caspofungin Acetate.

Brand names

Caspofungin Acetate7,697

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking caspofungin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.