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Carfilzomib Side Effects

The most commonly reported side effects of carfilzomib include plasma cell myeloma, off label use, and death, based on 27,565 FDA adverse event reports from 2010 to 2025. 3.0% of reports found the drug to be ineffective.

Carfilzomib side effects

Percentages show how often each reaction appears relative to total reports for carfilzomib.

1
Plasma Cell Myeloma10.8%2,966
2
Off Label Use8.3%2,294
3
Death6.3%1,741
4
Fatigue5.5%1,518
5
Thrombocytopenia5.4%1,476
6
Pneumonia4.9%1,348
7
Pyrexia4.2%1,159
8
Dyspnoea4.0%1,109
9
Diarrhoea4.0%1,098
10
Anaemia3.9%1,084
11
Neutropenia3.9%1,063
12
Nausea3.8%1,045
13
Acute Kidney Injury3.1%847
14
Drug Ineffective3.0%822
15
Asthenia2.6%705

These are voluntary reports and do not establish that carfilzomib caused these reactions.

Report severity

76.7%Serious21,141 reports
33.8%Hospitalizations9,315 reports
15.5%Fatal4,285 reports

Seriousness is determined by the reporter, not by OpenClaim.

Carfilzomib drug interactions

Other drugs that appear in adverse event reports alongside carfilzomib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone34.8%9,603
2
Lenalidomide31.0%8,548
3
Pomalidomide15.4%4,244
4
Daratumumab11.4%3,140
5
Bortezomib9.0%2,480
6
Cyclophosphamide8.0%2,198
7
Isatuximab-irfc7.0%1,926
8
Melphalan3.3%906
9
Thalidomide3.3%905
10
Doxorubicin-hydrochloride2.7%740
11
Etoposide2.4%651
12
Elotuzumab2.2%597
13
Selinexor2.1%588
14
Cisplatin1.9%530
15
Ixazomib-citrate1.4%384

Taken alongside

1
Dexamethasone25.6%7,069
2
Acyclovir14.3%3,940
3
Aspirin9.1%2,522
4
Lenalidomide7.0%1,943
5
Acetaminophen6.5%1,791
6
Omeprazole5.2%1,427
7
Ondansetron5.2%1,420
8
Zoledronic-acid5.1%1,395
9
Sulfamethoxazole4.3%1,181
10
Pantoprazole-sodium4.2%1,170
11
Cyclophosphamide4.2%1,158
12
Bortezomib4.0%1,115
13
Trimethoprim4.0%1,091
14
Daratumumab3.8%1,052
15
Amlodipine3.6%1,000

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports carfilzomib side effects

36.2% of carfilzomib adverse event reports involve female patients and 44.6% involve male patients. The largest age group is elderly at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.2%
Male44.6%
Unknown19.3%

Age group

< 2<0.1%
2–110.3%
12–170.2%
18–6446.8%
65+52.8%

What is carfilzomib used for

Conditions and purposes for which patients were taking carfilzomib when the adverse event was reported.

AcromegalyAcute Graft Versus Host DiseaseAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Lymphocytic Leukaemia RefractoryAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAcute Myeloid Leukemia RecurrentAdrenal AdenomaAdult T-cell Lymphoma/leukaemiaAmyloidosisAngioimmunoblastic T-cell LymphomaAntibody Test AbnormalAnticoagulant Therapy

Showing 15 of 252 indications

Carfilzomib brand names and reporting trend

Carfilzomib is sold under the brand name Carfilzomib.

Brand names

Carfilzomib22,939

Quarterly reports (20102025)

201020122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking carfilzomib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.