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Carbidopa Side Effects

The most commonly reported side effects of carbidopa include fall, death, and hallucination, based on 83,965 FDA adverse event reports from 2004 to 2025. 6.9% of reports found the drug to be ineffective.

Carbidopa side effects

Percentages show how often each reaction appears relative to total reports for carbidopa.

1
Fall9.4%7,881
2
Death8.3%6,990
3
Hallucination8.0%6,693
4
Drug Ineffective6.9%5,821
5
Dyskinesia6.3%5,307
6
Parkinson^s Disease5.7%4,753
7
Tremor5.4%4,509
8
Gait Disturbance4.2%3,505
9
Dizziness4.1%3,449
10
Confusional State4.0%3,382
11
Fatigue3.9%3,274
12
Nausea3.8%3,166
13
Somnolence3.4%2,818
14
On And Off Phenomenon3.4%2,817
15
Asthenia3.4%2,815

These are voluntary reports and do not establish that carbidopa caused these reactions.

Report severity

66.7%Serious56,001 reports
33.2%Hospitalizations27,884 reports
17.4%Fatal14,642 reports

Seriousness is determined by the reporter, not by OpenClaim.

Carbidopa drug interactions

Other drugs that appear in adverse event reports alongside carbidopa. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levodopa57.3%48,102
2
Pimavanserin13.0%10,905
3
Entacapone5.9%4,975
4
Apomorphine-hydrochloride3.1%2,635
5
Istradefylline2.5%2,135
6
Amantadine2.3%1,944
7
Rotigotine1.9%1,576
8
Pramipexole-dihydrochloride1.8%1,496
9
Ropinirole-hydrochloride1.7%1,406
10
Rasagiline-mesylate1.4%1,210
11
Droxidopa1.2%974
12
Quetiapine-fumarate1.1%956
13
Clozapine1.0%817
14
Rivastigmine0.7%625
15
Lenalidomide0.6%514

Taken alongside

1
Levodopa44.9%37,694
2
Aspirin10.7%8,968
3
Ergocalciferol9.2%7,732
4
Entacapone7.9%6,649
5
Atorvastatin-calcium7.7%6,430
6
Levothyroxine-sodium7.5%6,276
7
Amantadine7.4%6,250
8
Acetaminophen7.4%6,237
9
Quetiapine-fumarate6.9%5,794
10
Omeprazole6.5%5,451
11
Clonazepam6.5%5,449
12
Pramipexole-dihydrochloride6.2%5,220
13
Gabapentin6.1%5,092
14
Rasagiline-mesylate5.7%4,818
15
Ropinirole-hydrochloride5.5%4,595

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports carbidopa side effects

40.0% of carbidopa adverse event reports involve female patients and 53.7% involve male patients. The largest age group is elderly at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.0%
Male53.7%
Unknown6.3%

Age group

< 2<0.1%
2–110.1%
12–170.2%
18–6419.2%
65+80.5%

What is carbidopa used for

Conditions and purposes for which patients were taking carbidopa when the adverse event was reported.

AbasiaAbnormal BehaviourAbnormal FaecesAccidental ExposureAccidental OverdoseAgitationAkathisiaAkinesiaAltered State Of ConsciousnessAlzheimer^s DiseaseAnaemiaAnhedoniaAnorexiaAntibiotic TherapyAnxiety

Showing 15 of 476 indications

Carbidopa brand names and reporting trend

Carbidopa is sold under brand names including Lodosyn, Carbidopa And Levodopa.

Brand names

Lodosyn11,254
Carbidopa And Levodopa25

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking carbidopa with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.