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Carbamazepine Side Effects

The most commonly reported side effects of carbamazepine include seizure, off label use, and toxicity to various agents, based on 71,432 FDA adverse event reports from 2004 to 2025. 6.1% of reports found the drug to be ineffective.

Carbamazepine side effects

Percentages show how often each reaction appears relative to total reports for carbamazepine.

1
Drug Ineffective6.1%4,391
2
Seizure5.2%3,738
3
Off Label Use3.6%2,573
4
Toxicity To Various Agents3.6%2,537
5
Fall3.5%2,531
6
Drug Interaction3.5%2,467
7
Dizziness3.0%2,123
8
No Adverse Event2.9%2,055
9
Fatigue2.8%2,014
10
Nausea2.8%2,000
11
Convulsion2.8%1,995
12
Pain2.7%1,953
13
Pyrexia2.6%1,852
14
Vomiting2.6%1,835
15
Rash2.4%1,738

These are voluntary reports and do not establish that carbamazepine caused these reactions.

Report severity

83.1%Serious59,368 reports
37.5%Hospitalizations26,779 reports
8.2%Fatal5,892 reports

Seriousness is determined by the reporter, not by OpenClaim.

Carbamazepine drug interactions

Other drugs that appear in adverse event reports alongside carbamazepine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levetiracetam8.7%6,180
2
Lamotrigine5.2%3,745
3
Topiramate3.6%2,558
4
Phenytoin3.5%2,509
5
Quetiapine-fumarate3.2%2,309
6
Valproic-acid3.2%2,259
7
Lacosamide3.1%2,206
8
Gabapentin2.9%2,084
9
Pregabalin2.5%1,759
10
Clonazepam2.4%1,721
11
Acetaminophen2.4%1,713
12
Olanzapine2.2%1,589
13
Clobazam2.2%1,561
14
Risperidone2.0%1,458
15
Diazepam2.0%1,430

Taken alongside

1
Acetaminophen6.4%4,541
2
Aspirin5.4%3,891
3
Gabapentin5.4%3,824
4
Levothyroxine-sodium4.9%3,468
5
Ergocalciferol4.0%2,836
6
Levetiracetam3.9%2,819
7
Omeprazole3.9%2,813
8
Clonazepam3.8%2,734
9
Atorvastatin-calcium3.7%2,648
10
Amlodipine3.4%2,417
11
Lamotrigine3.2%2,294
12
Albuterol3.0%2,177
13
Furosemide3.0%2,145
14
Baclofen2.8%1,999
15
Folic-acid2.7%1,908

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports carbamazepine side effects

51.6% of carbamazepine adverse event reports involve female patients and 36.8% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.6%
Male36.8%
Unknown11.6%

Age group

< 23.1%
2–115.3%
12–174.3%
18–6464.1%
65+23.2%

What is carbamazepine used for

Conditions and purposes for which patients were taking carbamazepine when the adverse event was reported.

Abdominal NeoplasmAbdominal PainAbdominal Pain UpperAbdominal RigidityAbnormal BehaviourAbsence SeizureAbstains From AlcoholAccidental Drug Intake By ChildAccidental ExposureAccidental Exposure To ProductAccidental OverdoseAccidental PoisoningAcute Febrile Neutrophilic DermatosisAcute Kidney InjuryAcute Lymphocytic Leukaemia

Showing 15 of 1,485 indications

Carbamazepine brand names and reporting trend

Carbamazepine is sold under the brand name Carnexiv.

Brand names

Carnexiv46,256

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking carbamazepine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.