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Captopril Side Effects

The most commonly reported side effects of captopril include dyspnoea, hypertension, and diarrhoea, based on 10,621 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Captopril side effects

Percentages show how often each reaction appears relative to total reports for captopril.

1
Drug Ineffective3.9%414
2
Dyspnoea3.3%351
3
Hypertension3.2%340
4
Diarrhoea3.2%335
5
Nausea3.1%334
6
Dyspnoea3.1%326
7
Pain2.7%283
8
Off Label Use2.6%277
9
Fatigue2.5%269
10
Headache2.5%264
11
Malaise2.4%255
12
Asthenia2.4%252
13
Hypertension2.3%247
14
Dizziness2.3%246
15
Dizziness2.3%240

These are voluntary reports and do not establish that captopril caused these reactions.

Report severity

88.9%Serious9,445 reports
50.8%Hospitalizations5,393 reports
16.1%Fatal1,712 reports

Seriousness is determined by the reporter, not by OpenClaim.

Captopril drug interactions

Other drugs that appear in adverse event reports alongside captopril. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Furosemide3.9%412
2
Amlodipine3.8%406
3
Adalimumab3.3%348
4
Hydrochlorothiazide3.0%315
5
Metformin2.8%296
6
Aspirin2.6%278
7
Omeprazole2.5%263
8
Rosiglitazone-maleate2.4%255
9
Insulin2.4%253
10
Valsartan2.3%246
11
Digoxin2.2%238
12
Atorvastatin-calcium1.9%206
13
Clopidogrel-bisulfate1.8%190
14
Metoprolol1.7%183
15
Palivizumab1.6%167

Taken alongside

1
Furosemide19.9%2,118
2
Aspirin17.0%1,810
3
Hydrochlorothiazide10.4%1,103
4
Metformin10.0%1,067
5
Omeprazole9.8%1,037
6
Acetaminophen9.7%1,035
7
Amlodipine9.2%978
8
Metoprolol9.1%971
9
Simvastatin8.6%912
10
Atorvastatin-calcium8.2%870
11
Insulin7.4%781
12
Spironolactone7.1%749
13
Levothyroxine-sodium6.9%735
14
Prednisone6.4%675
15
Digoxin6.1%644

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports captopril side effects

52.2% of captopril adverse event reports involve female patients and 42.7% involve male patients. The largest age group is elderly at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.2%
Male42.7%
Unknown5.2%

Age group

< 24.6%
2–113.1%
12–171.9%
18–6442.4%
65+48.0%

What is captopril used for

Conditions and purposes for which patients were taking captopril when the adverse event was reported.

Abdominal Pain UpperAccelerated HypertensionAcute Coronary SyndromeAcute Myocardial InfarctionAcute Pulmonary OedemaAdjuvant TherapyAmyloidosisAngina PectorisAnkylosing SpondylitisAnticoagulant TherapyAntiplatelet TherapyAnxietyAortic Valve IncompetenceAortic Valve ReplacementArrhythmia

Showing 15 of 309 indications

Captopril brand names and reporting trend

Captopril is sold under the brand name Captopril And Hydrochlorothiazide.

Brand names

Captopril And Hydrochlorothiazide10,141

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking captopril with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.