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Capmatinib Side Effects

The most commonly reported side effects of capmatinib include death, peripheral swelling, and fatigue, based on 2,308 FDA adverse event reports from 2008 to 2025. 2.6% of reports found the drug to be ineffective.

Capmatinib side effects

Percentages show how often each reaction appears relative to total reports for capmatinib.

1
Death17.7%409
2
Peripheral Swelling12.4%286
3
Fatigue11.1%257
4
Oedema Peripheral10.5%242
5
Nausea10.4%239
6
Malignant Neoplasm Progression7.8%179
7
Dyspnoea5.8%135
8
Oedema5.7%131
9
Asthenia4.9%112
10
Decreased Appetite4.2%98
11
Non-small Cell Lung Cancer4.1%95
12
Joint Swelling4.0%92
13
Vomiting3.6%84
14
Dysphagia3.6%82
15
Product Dose Omission Issue3.3%76

These are voluntary reports and do not establish that capmatinib caused these reactions.

Report severity

60.2%Serious1,390 reports
16.4%Hospitalizations379 reports
24.3%Fatal560 reports

Seriousness is determined by the reporter, not by OpenClaim.

Capmatinib drug interactions

Other drugs that appear in adverse event reports alongside capmatinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Osimertinib-mesylate1.3%31
2
Pembrolizumab1.3%30
3
Carboplatin1.0%23
4
Paclitaxel0.9%20
5
Apixaban0.8%18
6
Cabozantinib0.6%15
7
Acetaminophen0.6%15
8
Hydromorphone-hydrochloride0.6%14
9
Torsemide0.6%14
10
Pemetrexed0.6%13
11
Crizotinib0.5%12
12
Lorlatinib0.4%10
13
Atezolizumab0.4%9
14
Cisplatin0.4%9
15
Bevacizumab0.4%9

Taken alongside

1
Acetaminophen2.8%65
2
Levothyroxine-sodium2.1%48
3
Ergocalciferol2.0%47
4
Omeprazole1.8%42
5
Furosemide1.8%42
6
Apixaban1.6%37
7
Calcium1.6%36
8
Ondansetron1.5%35
9
Aspirin1.5%34
10
Folic-acid1.4%32
11
Atorvastatin-calcium1.3%31
12
Amlodipine1.3%31
13
Metformin1.3%29
14
Pantoprazole-sodium1.2%28
15
Dexamethasone1.2%27

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports capmatinib side effects

48.3% of capmatinib adverse event reports involve female patients and 39.8% involve male patients. The largest age group is elderly at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.3%
Male39.8%
Unknown11.9%

Age group

< 20.1%
2–110.2%
12–170.1%
18–6425.0%
65+74.5%

What is capmatinib used for

Conditions and purposes for which patients were taking capmatinib when the adverse event was reported.

Adenocarcinoma MetastaticAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdrenal MassAnaemiaAnaplastic Lymphoma Kinase Gene MutationAstrocytomaBraf V600e Mutation PositiveBrain Neoplasm MalignantBreast CancerBronchial CarcinomaBone CancerBrain NeoplasmBrain Neoplasm Malignant

Showing 15 of 136 indications

Capmatinib brand names and reporting trend

Capmatinib is sold under the brand name Tabrecta.

Brand names

Tabrecta604

Quarterly reports (20082025)

200820202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking capmatinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.