OpenClaim

Calfactant Side Effects

The most commonly reported side effects of calfactant include endotracheal intubation complication, neonatal disorder, and oxygen saturation decreased, based on 101 FDA adverse event reports from 2004 to 2023.

Calfactant side effects

Percentages show how often each reaction appears relative to total reports for calfactant.

1
Endotracheal Intubation Complication24.8%25
2
Neonatal Disorder15.8%16
3
Oxygen Saturation Decreased12.9%13
4
Pneumothorax8.9%9
5
Endotracheal Intubation Complication8.9%9
6
Oxygen Saturation Decreased7.9%8
7
Pulmonary Haemorrhage6.9%7
8
Bradycardia5.9%6
9
Pulmonary Interstitial Emphysema Syndrome5.0%5
10
Obstructive Airways Disorder5.0%5
11
Cardio-respiratory Arrest5.0%5
12
Premature Baby4.0%4
13
Metabolic Acidosis4.0%4
14
Neonatal Hypotension4.0%4
15
Neonatal Respiratory Failure4.0%4

These are voluntary reports and do not establish that calfactant caused these reactions.

Report severity

97.0%Serious98 reports
12.9%Hospitalizations13 reports
28.7%Fatal29 reports

Seriousness is determined by the reporter, not by OpenClaim.

Calfactant drug interactions

Other drugs that appear in adverse event reports alongside calfactant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Beractant8.9%9
2
Ibuprofen3.0%3
3
Dextrose1.0%1
4
Calcium-gluconate1.0%1
5
Heparin1.0%1
6
Acetaminophen1.0%1
7
Gentamicin-sulfate1.0%1
8
Indomethacin1.0%1
9
Amphotericin-b1.0%1
10
Dexamethasone1.0%1

Taken alongside

1
Ampicillin14.9%15
2
Indomethacin9.9%10
3
Dopamine-hydrochloride7.9%8
4
Gentamicin-sulfate7.9%8
5
Cefotaxime-sodium5.9%6
6
Dobutamine-hydrochloride5.9%6
7
Caffeine5.0%5
8
Fentanyl4.0%4
9
Dexamethasone4.0%4
10
Midazolam4.0%4
11
Epinephrine4.0%4
12
Calcium-gluconate4.0%4
13
Erythromycin4.0%4
14
Dextrose4.0%4
15
Meropenem3.0%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports calfactant side effects

34.7% of calfactant adverse event reports involve female patients and 32.7% involve male patients. The largest age group is neonate at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.7%
Male32.7%
Unknown32.7%

Age group

< 298.5%
2–110.0%
12–170.0%
18–641.5%
65+0.0%

What is calfactant used for

Conditions and purposes for which patients were taking calfactant when the adverse event was reported.

Acute Respiratory Distress SyndromeApgar Score LowNeonatal Respiratory Distress SyndromeNeonatal Respiratory Distress Syndrome ProphylaxisNeonatal Respiratory Distress SyndromePremature BabyProduct Used For Unknown IndicationProphylaxisProduct Used For Unknown IndicationRespiratory Distress

Calfactant brand names and reporting trend

Calfactant is sold under the brand name Infasurf Preservative Free.

Brand names

Infasurf Preservative Free8

Quarterly reports (20042023)

2004201520202023

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking calfactant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.