OpenClaim

Calcium Gluconate Side Effects

The most commonly reported side effects of calcium gluconate include off label use, pain, and fatigue, based on 11,945 FDA adverse event reports from 2004 to 2025. 15.6% of reports found the drug to be ineffective.

Calcium Gluconate side effects

Percentages show how often each reaction appears relative to total reports for calcium gluconate.

1
Drug Ineffective15.6%1,858
2
Off Label Use12.8%1,533
3
Pain12.3%1,471
4
Fatigue11.8%1,412
5
Rheumatoid Arthritis11.0%1,310
6
Alopecia10.4%1,241
7
Pemphigus10.1%1,204
8
Psoriatic Arthropathy10.0%1,199
9
Abdominal Discomfort9.9%1,186
10
Arthropathy9.9%1,179
11
Systemic Lupus Erythematosus9.8%1,171
12
Glossodynia9.4%1,123
13
Liver Injury9.0%1,076
14
Condition Aggravated8.6%1,029
15
Vomiting8.5%1,021

These are voluntary reports and do not establish that calcium gluconate caused these reactions.

Report severity

81.9%Serious9,788 reports
45.6%Hospitalizations5,451 reports
20.4%Fatal2,431 reports

Seriousness is determined by the reporter, not by OpenClaim.

Calcium Gluconate drug interactions

Other drugs that appear in adverse event reports alongside calcium gluconate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab20.9%2,495
2
Prednisone17.2%2,060
3
Infliximab16.6%1,979
4
Methotrexate15.6%1,858
5
Rituximab15.1%1,804
6
Abatacept14.8%1,764
7
Etanercept14.1%1,680
8
Tocilizumab13.7%1,636
9
Cetirizine-hydrochloride13.7%1,635
10
Folic-acid13.5%1,614
11
Leflunomide13.5%1,610
12
Diclofenac13.2%1,579
13
Desoximetasone13.2%1,577
14
Hydroxychloroquine-sulfate13.0%1,555
15
Certolizumab-pegol12.8%1,534

Taken alongside

1
Acetaminophen24.3%2,898
2
Pantoprazole-sodium21.7%2,590
3
Ergocalciferol18.9%2,257
4
Furosemide13.9%1,658
5
Potassium-chloride13.2%1,575
6
Aspirin13.0%1,558
7
Quetiapine-fumarate13.0%1,555
8
Lorazepam11.8%1,409
9
Ibuprofen11.8%1,409
10
Ramipril11.7%1,403
11
Levothyroxine-sodium11.6%1,389
12
Lisinopril11.5%1,372
13
Prednisone11.2%1,333
14
Folic-acid10.3%1,232
15
Dexamethasone10.0%1,189

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports calcium gluconate side effects

64.4% of calcium gluconate adverse event reports involve female patients and 27.9% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female64.4%
Male27.9%
Unknown7.7%

Age group

< 23.4%
2–111.8%
12–171.2%
18–6453.4%
65+40.2%

What is calcium gluconate used for

Conditions and purposes for which patients were taking calcium gluconate when the adverse event was reported.

Acute Coronary SyndromeAcute Kidney InjuryAdenocarcinomaAdjuvant TherapyAdverse Drug ReactionAdverse EventAllergy ProphylaxisAnaemiaAnaesthesiaAnaphylactic ReactionAnaphylaxis TreatmentAntiallergic TherapyApheresisArteriovenous Fistula OperationArthritis

Showing 15 of 414 indications

Calcium Gluconate brand names and reporting trend

Calcium Gluconate is sold under the brand name Calcium Gluconate.

Brand names

Calcium Gluconate13,391

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking calcium gluconate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.