OpenClaim

Calcium Acetate Side Effects

The most commonly reported side effects of calcium acetate include chronic kidney disease, renal failure, and end stage renal disease, based on 8,304 FDA adverse event reports from 2004 to 2025. 2.4% of reports found the drug to be ineffective.

Calcium Acetate side effects

Percentages show how often each reaction appears relative to total reports for calcium acetate.

1
Chronic Kidney Disease7.0%578
2
Renal Failure6.9%574
3
End Stage Renal Disease6.6%544
4
Acute Kidney Injury5.8%480
5
Diarrhoea4.6%379
6
Death4.0%335
7
Fatigue3.8%315
8
Nausea3.6%296
9
Nephrogenic Anaemia3.3%275
10
Dyspnoea2.9%240
11
Nausea2.8%234
12
Pain2.8%229
13
Off Label Use2.4%201
14
Nephrogenic Systemic Fibrosis2.4%200
15
Drug Ineffective2.4%197

These are voluntary reports and do not establish that calcium acetate caused these reactions.

Report severity

76.8%Serious6,380 reports
43.8%Hospitalizations3,639 reports
15.6%Fatal1,295 reports

Seriousness is determined by the reporter, not by OpenClaim.

Calcium Acetate drug interactions

Other drugs that appear in adverse event reports alongside calcium acetate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide6.2%515
2
Omeprazole5.8%483
3
Dextrose5.8%479
4
Esomeprazole5.5%456
5
Sodium-chloride5.2%428
6
Patiromer-sorbitex-calcium4.4%363
7
Pantoprazole-sodium4.2%347
8
Magnesium-chloride4.0%333
9
Calcium-chloride3.9%322
10
Sodium-lactate3.9%322
11
Lansoprazole3.7%310
12
Gadopentetate-dimeglumine2.8%233
13
Niacin2.8%231
14
Cinacalcet-hydrochloride2.7%224
15
Heparin2.6%217

Taken alongside

1
Aspirin28.4%2,362
2
Acetaminophen23.3%1,935
3
Amlodipine23.1%1,915
4
Ergocalciferol20.7%1,721
5
Furosemide20.5%1,704
6
Metoprolol20.2%1,680
7
Insulin19.3%1,606
8
Atorvastatin-calcium18.1%1,499
9
Carvedilol15.4%1,281
10
Levothyroxine-sodium14.2%1,179
11
Sevelamer14.0%1,159
12
Omeprazole13.6%1,131
13
Gabapentin13.1%1,090
14
Lisinopril12.6%1,049
15
Pantoprazole-sodium12.3%1,021

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports calcium acetate side effects

46.6% of calcium acetate adverse event reports involve female patients and 48.2% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.6%
Male48.2%
Unknown5.2%

Age group

< 20.4%
2–110.6%
12–170.7%
18–6457.5%
65+40.8%

What is calcium acetate used for

Conditions and purposes for which patients were taking calcium acetate when the adverse event was reported.

Accidental Exposure To Product By ChildAccidental OverdoseAcute Kidney InjuryAdverse Drug ReactionAnticoagulant TherapyArthritisAcute Kidney InjuryAcute Lymphocytic LeukaemiaAlbright^s DiseaseAntiallergic TherapyBlood Acid PhosphataseBlood CalciumBlood Calcium AbnormalBlood Calcium DecreasedBlood Phosphorus

Showing 15 of 230 indications

Calcium Acetate brand names and reporting trend

Calcium Acetate is sold under the brand name Phoslyra.

Brand names

Phoslyra5,595

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking calcium acetate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.