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Calcitriol Side Effects

The most commonly reported side effects of calcitriol include nausea, chronic kidney disease, and off label use, based on 24,382 FDA adverse event reports from 2004 to 2025. 3.1% of reports found the drug to be ineffective.

Calcitriol side effects

Percentages show how often each reaction appears relative to total reports for calcitriol.

1
Nausea5.8%1,409
2
Chronic Kidney Disease5.1%1,234
3
Off Label Use5.0%1,221
4
Diarrhoea4.8%1,181
5
Renal Failure4.6%1,113
6
Acute Kidney Injury4.5%1,096
7
Dyspnoea4.3%1,040
8
Fatigue4.1%1,011
9
Vomiting4.1%998
10
Death3.9%947
11
Drug Hypersensitivity3.5%846
12
Headache3.2%785
13
End Stage Renal Disease3.2%785
14
Drug Ineffective3.1%757
15
Asthenia3.0%740

These are voluntary reports and do not establish that calcitriol caused these reactions.

Report severity

80.1%Serious19,528 reports
44.7%Hospitalizations10,889 reports
13.4%Fatal3,261 reports

Seriousness is determined by the reporter, not by OpenClaim.

Calcitriol drug interactions

Other drugs that appear in adverse event reports alongside calcitriol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dextrose5.0%1,226
2
Lenalidomide4.9%1,194
3
Parathyroid-hormone4.0%966
4
Methoxy-polyethylene-glycol-epoetin-beta3.9%962
5
Omeprazole3.9%945
6
Lansoprazole3.7%892
7
Pantoprazole-sodium3.6%884
8
Esomeprazole3.6%871
9
Darbepoetin-alfa3.4%835
10
Tacrolimus2.7%666
11
Patiromer-sorbitex-calcium2.7%652
12
Adalimumab2.6%628
13
Sodium-chloride2.5%615
14
Mycophenolate2.4%574
15
Calcium-carbonate2.2%538

Taken alongside

1
Aspirin20.6%5,022
2
Furosemide20.3%4,949
3
Amlodipine18.7%4,567
4
Levothyroxine-sodium18.6%4,547
5
Ergocalciferol17.6%4,294
6
Atorvastatin-calcium15.3%3,737
7
Acetaminophen15.0%3,661
8
Metoprolol14.3%3,475
9
Insulin12.4%3,029
10
Omeprazole12.4%3,014
11
Calcium11.8%2,889
12
Allopurinol11.0%2,685
13
Prednisone10.2%2,493
14
Pantoprazole-sodium10.1%2,468
15
Carvedilol8.8%2,147

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports calcitriol side effects

51.1% of calcitriol adverse event reports involve female patients and 41.4% involve male patients. The largest age group is elderly at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.1%
Male41.4%
Unknown7.5%

Age group

< 20.9%
2–111.9%
12–171.6%
18–6447.4%
65+48.2%

What is calcitriol used for

Conditions and purposes for which patients were taking calcitriol when the adverse event was reported.

Acute Kidney InjuryAcute Myeloid LeukaemiaAddison^s DiseaseAdjuvant TherapyAdverse EventAgitationAlagille SyndromeAlbright^s DiseaseAmyloidosisAnaemiaAnaplastic Thyroid CancerAnkylosing SpondylitisArthritisAstheniaAzotaemia

Showing 15 of 446 indications

Calcitriol brand names and reporting trend

Calcitriol is sold under the brand name Rocaltrol.

Brand names

Rocaltrol21,886

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking calcitriol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.