OpenClaim

Calaspargase Side Effects

The most commonly reported side effects of calaspargase include hypersensitivity, anaphylactic reaction, and pancreatitis, based on 716 FDA adverse event reports from 2005 to 2025.

Calaspargase side effects

Percentages show how often each reaction appears relative to total reports for calaspargase.

1
Hypersensitivity25.8%185
2
Anaphylactic Reaction13.4%96
3
Pancreatitis9.1%65
4
Infusion Related Reaction8.7%62
5
Hypertriglyceridaemia6.6%47
6
Vomiting6.3%45
7
Febrile Neutropenia4.6%33
8
Neutropenia3.6%26
9
Tachycardia3.5%25
10
Nausea3.4%24
11
Cough2.9%21
12
Venoocclusive Liver Disease2.8%20
13
Pancreatitis Acute2.7%19
14
Septic Shock2.7%19
15
Hyperglycaemia2.5%18

These are voluntary reports and do not establish that calaspargase caused these reactions.

Report severity

91.2%Serious653 reports
44.4%Hospitalizations318 reports
8.7%Fatal62 reports

Seriousness is determined by the reporter, not by OpenClaim.

Calaspargase drug interactions

Other drugs that appear in adverse event reports alongside calaspargase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Vincristine-sulfate13.8%99
2
Methotrexate12.0%86
3
Cytarabine10.1%72
4
Dexamethasone9.4%67
5
Cyclophosphamide5.0%36
6
Daunorubicin4.7%34
7
Doxorubicin-hydrochloride4.6%33
8
Mercaptopurine3.4%24
9
Prednisolone3.1%22
10
Thioguanine2.9%21
11
Dexrazoxane-hydrochloride2.4%17
12
Imatinib-mesylate2.1%15
13
Leucovorin-calcium1.8%13
14
Prednisone1.7%12
15
Asparaginase1.7%12

Taken alongside

1
Diphenhydramine14.4%103
2
Famotidine14.4%103
3
Vincristine-sulfate9.9%71
4
Methotrexate7.3%52
5
Acetaminophen7.3%52
6
Ondansetron6.0%43
7
Dexamethasone5.0%36
8
Mercaptopurine4.6%33
9
Cytarabine4.1%29
10
Hydrocortisone3.5%25
11
Prednisone2.7%19
12
Sulfamethoxazole2.5%18
13
Trimethoprim2.4%17
14
Cyclophosphamide2.2%16
15
Cetirizine-hydrochloride2.0%14

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports calaspargase side effects

17.0% of calaspargase adverse event reports involve female patients and 19.8% involve male patients. The largest age group is child at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female17.0%
Male19.8%
Unknown63.1%

Age group

< 20.8%
2–1149.2%
12–1730.0%
18–6418.8%
65+1.2%

What is calaspargase used for

Conditions and purposes for which patients were taking calaspargase when the adverse event was reported.

Acute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia (in Remission)Acute Myeloid LeukaemiaAdenocarcinoma PancreasB Precursor Type Acute LeukaemiaB-cell Lymphoma Stage IiB-cell Type Acute LeukaemiaChemotherapyChronic Myeloid LeukaemiaDuctal Adenocarcinoma Of PancreasLymphomaLeukaemiaLeukaemia RecurrentMetastasis

Showing 15 of 28 indications

Calaspargase brand names and reporting trend

Calaspargase is sold under the brand name Asparlas.

Brand names

Asparlas257

Quarterly reports (20052025)

20052025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking calaspargase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.