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Cabozantinib Side Effects

The most commonly reported side effects of cabozantinib include diarrhoea, fatigue, and off label use, based on 43,592 FDA adverse event reports from 2012 to 2025.

Cabozantinib side effects

Percentages show how often each reaction appears relative to total reports for cabozantinib.

1
Diarrhoea20.5%8,928
2
Fatigue16.7%7,295
3
Off Label Use13.1%5,689
4
Nausea10.8%4,706
5
Decreased Appetite10.1%4,403
6
Malignant Neoplasm Progression7.0%3,062
7
Blood Pressure Increased7.0%3,038
8
Palmar-plantar Erythrodysaesthesia Syndrome6.7%2,899
9
Weight Decreased6.6%2,862
10
Stomatitis6.4%2,777
11
Death6.3%2,748
12
Constipation5.1%2,243
13
Vomiting4.8%2,093
14
Asthenia4.7%2,039
15
Blister4.6%2,015

These are voluntary reports and do not establish that cabozantinib caused these reactions.

Report severity

43.9%Serious19,150 reports
19.6%Hospitalizations8,543 reports
11.6%Fatal5,037 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cabozantinib drug interactions

Other drugs that appear in adverse event reports alongside cabozantinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nivolumab13.4%5,833
2
Ipilimumab1.8%771
3
Atezolizumab1.4%618
4
Lenvatinib-mesylate1.2%538
5
Everolimus0.9%379
6
Pembrolizumab0.8%345
7
Axitinib0.6%242
8
Sunitinib-malate0.4%159
9
Denosumab0.3%134
10
Apixaban0.3%112
11
Bevacizumab0.2%105
12
Pazopanib-hydrochloride0.2%101
13
Prednisone0.2%82
14
Zoledronic-acid0.2%77
15
Sorafenib-tosylate0.2%76

Taken alongside

1
Levothyroxine-sodium11.0%4,814
2
Amlodipine7.9%3,463
3
Acetaminophen6.8%2,965
4
Ondansetron5.6%2,447
5
Ergocalciferol5.2%2,271
6
Aspirin4.7%2,061
7
Oxycodone4.7%2,061
8
Atorvastatin-calcium4.7%2,051
9
Omeprazole4.5%1,972
10
Metoprolol4.4%1,936
11
Lisinopril3.9%1,720
12
Pantoprazole-sodium3.4%1,491
13
Gabapentin3.4%1,476
14
Metformin3.1%1,369
15
Prednisone2.9%1,271

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cabozantinib side effects

27.4% of cabozantinib adverse event reports involve female patients and 66.0% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female27.4%
Male66.0%
Unknown6.5%

Age group

< 2<0.1%
2–110.3%
12–170.5%
18–6443.0%
65+56.2%

What is cabozantinib used for

Conditions and purposes for which patients were taking cabozantinib when the adverse event was reported.

Acute Kidney InjuryAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma PancreasAdenosquamous Cell CarcinomaAdrenal Gland CancerAdrenal Gland Cancer MetastaticAdrenocortical CarcinomaAdverse ReactionAffective DisorderAge-related Macular DegenerationAlveolar RhabdomyosarcomaAlveolar Soft Part Sarcoma

Showing 15 of 884 indications

Cabozantinib brand names and reporting trend

Cabozantinib is sold under brand names including Resniben, Cabometyx.

Brand names

Resniben4,888
Cabometyx112

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cabozantinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.