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Butabarbital Side Effects

The most commonly reported side effects of butabarbital include anxiety, pain, and headache, based on 60 FDA adverse event reports from 2004 to 2025.

Butabarbital side effects

Percentages show how often each reaction appears relative to total reports for butabarbital.

1
Anxiety15.0%9
2
Pain10.0%6
3
Headache8.3%5
4
Drug Hypersensitivity8.3%5
5
Fatigue8.3%5
6
Migraine8.3%5
7
Hypotension8.3%5
8
Metabolic Acidosis8.3%5
9
Hepatotoxicity8.3%5
10
Coagulopathy8.3%5
11
Leukocytosis8.3%5
12
Acute Kidney Injury8.3%5
13
Rhabdomyolysis8.3%5
14
Headache6.7%4
15
Dyspnoea6.7%4

These are voluntary reports and do not establish that butabarbital caused these reactions.

Report severity

63.3%Serious38 reports
18.3%Hospitalizations11 reports
11.7%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Butabarbital drug interactions

Other drugs that appear in adverse event reports alongside butabarbital. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen11.7%7
2
Caffeine10.0%6
3
Adalimumab5.0%3
4
Hydrocodone5.0%3
5
Dihydrocodeine-bitartrate5.0%3
6
Hydroxyzine5.0%3
7
Secukinumab5.0%3
8
Amphetamine3.3%2
9
Methadone-hydrochloride3.3%2
10
Butalbital3.3%2
11
Oxycodone3.3%2
12
Meperidine-hydrochloride3.3%2
13
Alprazolam3.3%2
14
Buspirone-hydrochloride3.3%2
15
Secobarbital-sodium3.3%2

Taken alongside

1
Acetaminophen28.3%17
2
Levothyroxine-sodium20.0%12
3
Gabapentin20.0%12
4
Alprazolam18.3%11
5
Metoprolol18.3%11
6
Omeprazole18.3%11
7
Albuterol18.3%11
8
Aspirin16.7%10
9
Ergocalciferol16.7%10
10
Fluticasone13.3%8
11
Atorvastatin-calcium13.3%8
12
Hydrocodone11.7%7
13
Clonazepam11.7%7
14
Fluoxetine-hydrochloride11.7%7
15
Calcium11.7%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports butabarbital side effects

81.7% of butabarbital adverse event reports involve female patients and 10.0% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female81.7%
Male10.0%
Unknown8.3%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6466.7%
65+33.3%

What is butabarbital used for

Conditions and purposes for which patients were taking butabarbital when the adverse event was reported.

DepressionHeadacheInsomniaMigraineMigraineProduct Used For Unknown IndicationProduct Used For Unknown IndicationTension HeadacheTremor

Butabarbital brand names and reporting trend

Butabarbital is sold under the brand name Butabarbital.

Brand names

Butabarbital7

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking butabarbital with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.