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Buspirone Side Effects

The most commonly reported side effects of buspirone include fatigue, off label use, and nausea, based on 104,972 FDA adverse event reports from 2004 to 2025. 5.9% of reports found the drug to be ineffective.

Buspirone side effects

Percentages show how often each reaction appears relative to total reports for buspirone.

1
Fatigue7.4%7,802
2
Off Label Use6.3%6,572
3
Nausea6.1%6,442
4
Drug Ineffective5.9%6,212
5
Diarrhoea5.7%5,977
6
Headache5.1%5,302
7
Pain4.6%4,844
8
Dyspnoea4.3%4,476
9
Dizziness4.0%4,222
10
Arthralgia3.6%3,787
11
Vomiting3.3%3,468
12
Fall3.3%3,452
13
Anxiety3.2%3,376
14
Asthenia3.2%3,376
15
Malaise3.0%3,132

These are voluntary reports and do not establish that buspirone caused these reactions.

Report severity

62.6%Serious65,736 reports
29.4%Hospitalizations30,846 reports
7.5%Fatal7,844 reports

Seriousness is determined by the reporter, not by OpenClaim.

Buspirone drug interactions

Other drugs that appear in adverse event reports alongside buspirone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab6.6%6,949
2
Sodium-oxybate4.2%4,404
3
Lenalidomide4.0%4,206
4
Infliximab2.7%2,868
5
Dupilumab2.4%2,509
6
Vedolizumab2.2%2,317
7
Treprostinil1.8%1,893
8
Omeprazole1.7%1,780
9
Quetiapine-fumarate1.5%1,622
10
Etanercept1.5%1,594
11
Esomeprazole1.4%1,428
12
Pantoprazole-sodium1.3%1,401
13
Acetaminophen1.3%1,334
14
Pregabalin1.2%1,232
15
Sertraline-hydrochloride1.1%1,199

Taken alongside

1
Ergocalciferol24.8%26,037
2
Acetaminophen17.6%18,462
3
Aspirin16.8%17,660
4
Levothyroxine-sodium14.1%14,778
5
Omeprazole13.6%14,279
6
Gabapentin12.6%13,278
7
Calcium11.7%12,254
8
Furosemide11.6%12,141
9
Albuterol11.4%12,011
10
Atorvastatin-calcium11.0%11,594
11
Cyanocobalamin11.0%11,560
12
Prednisone10.4%10,931
13
Metoprolol10.1%10,622
14
Folic-acid9.4%9,906
15
Amlodipine9.2%9,696

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports buspirone side effects

65.6% of buspirone adverse event reports involve female patients and 27.2% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female65.6%
Male27.2%
Unknown7.2%

Age group

< 21.1%
2–111.0%
12–172.1%
18–6461.0%
65+34.8%

What is buspirone used for

Conditions and purposes for which patients were taking buspirone when the adverse event was reported.

11-beta-hydroxylase DeficiencyAbdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain UpperAbdominal Wall HaematomaAbnormal BehaviourAccident At WorkAccidental Drug Intake By ChildAccidental ExposureAcneAdjustment DisorderAdjuvant TherapyAdverse Drug ReactionAdverse Event

Showing 15 of 873 indications

Buspirone brand names and reporting trend

Buspirone is sold under the brand name Bucapsol.

Brand names

Bucapsol67,794

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking buspirone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.