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Burosumab Side Effects

The most commonly reported side effects of burosumab include inappropriate schedule of product administration, product dose omission issue, and blood phosphorus decreased, based on 6,018 FDA adverse event reports from 2004 to 2025.

Burosumab side effects

Percentages show how often each reaction appears relative to total reports for burosumab.

1
Inappropriate Schedule Of Product Administration11.5%692
2
Product Dose Omission Issue10.1%610
3
Blood Phosphorus Decreased9.5%574
4
Pain6.1%367
5
Arthralgia5.9%358
6
Pain In Extremity5.6%334
7
Restless Legs Syndrome4.5%270
8
Headache4.4%262
9
Incorrect Dose Administered4.1%244
10
Injection Site Pain3.9%233
11
Fatigue3.8%231
12
Bone Pain3.3%199
13
Contraindicated Product Administered3.2%191
14
Back Pain3.1%185
15
Covid-193.0%178

These are voluntary reports and do not establish that burosumab caused these reactions.

Report severity

21.3%Serious1,283 reports
7.2%Hospitalizations434 reports
0.6%Fatal34 reports

Seriousness is determined by the reporter, not by OpenClaim.

Burosumab drug interactions

Other drugs that appear in adverse event reports alongside burosumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ergocalciferol1.9%113
2
Calcitriol0.9%53
3
Hexocyclium-methylsulfate0.2%10
4
Sodium-phosphate0.1%9
5
Cholecalciferol0.1%7
6
Somatropin0.1%7
7
Cinacalcet-hydrochloride<0.1%6
8
Gemfibrozil<0.1%5
9
Sulfamethoxazole<0.1%4
10
Calcium-carbonate<0.1%3
11
Paricalcitol<0.1%3
12
Trimethoprim<0.1%3
13
Cefazolin-sodium<0.1%2
14
Oxycodone<0.1%2
15
Phosphoric-acid<0.1%2

Taken alongside

1
Ergocalciferol9.6%576
2
Acetaminophen5.4%326
3
Ibuprofen4.5%268
4
Cetirizine-hydrochloride2.7%164
5
Albuterol2.4%147
6
Gabapentin2.3%139
7
Omeprazole2.1%126
8
Fluticasone2.0%121
9
Levothyroxine-sodium1.8%111
10
Amlodipine1.8%107
11
Loratadine1.5%88
12
Oxycodone1.4%86
13
Duloxetine-hydrochloride1.4%85
14
Lisinopril1.4%85
15
Aspirin1.3%80

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports burosumab side effects

0.5% of burosumab adverse event reports involve female patients and 0.4% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female0.5%
Male0.4%
Unknown99.1%

Age group

< 24.3%
2–1127.7%
12–1712.8%
18–6446.8%
65+8.5%

What is burosumab used for

Conditions and purposes for which patients were taking burosumab when the adverse event was reported.

Albright^s DiseaseAcromegalyAlbright^s DiseaseAmino Acid Metabolism DisorderBlood Acid PhosphataseBone DisorderCalcium Metabolism DisorderCarnitine Palmitoyltransferase DeficiencyCongenital Connective Tissue DisorderDiabetes MellitusDermatophytosis Of NailDisease SusceptibilityEndocrine DisorderEpidermal Naevus SyndromeFall

Showing 15 of 63 indications

Burosumab brand names and reporting trend

Burosumab is sold under the brand name Crysvita.

Brand names

Crysvita1,995

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking burosumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.