OpenClaim

Bumetanide Side Effects

The most commonly reported side effects of bumetanide include dyspnoea, acute kidney injury, and fatigue, based on 25,432 FDA adverse event reports from 2004 to 2025. 2.8% of reports found the drug to be ineffective.

Bumetanide side effects

Percentages show how often each reaction appears relative to total reports for bumetanide.

1
Dyspnoea8.5%2,174
2
Acute Kidney Injury6.6%1,679
3
Fatigue5.9%1,506
4
Death5.9%1,504
5
Diarrhoea5.2%1,318
6
Nausea4.9%1,238
7
Dizziness4.1%1,046
8
Headache4.1%1,031
9
Pneumonia3.8%954
10
Chronic Kidney Disease3.5%896
11
Hypotension3.3%841
12
Renal Failure3.3%834
13
Asthenia3.2%820
14
Off Label Use3.1%777
15
Fall3.0%770

These are voluntary reports and do not establish that bumetanide caused these reactions.

Report severity

77.7%Serious19,749 reports
48.4%Hospitalizations12,300 reports
15.9%Fatal4,055 reports

Seriousness is determined by the reporter, not by OpenClaim.

Bumetanide drug interactions

Other drugs that appear in adverse event reports alongside bumetanide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Treprostinil9.5%2,408
2
Lenalidomide4.7%1,200
3
Omeprazole3.4%863
4
Apixaban3.3%831
5
Ambrisentan3.2%822
6
Spironolactone3.0%755
7
Macitentan2.9%744
8
Esomeprazole2.9%728
9
Valsartan2.6%659
10
Lansoprazole2.6%656
11
Pantoprazole-sodium2.5%642
12
Sacubitril2.2%547
13
Rivaroxaban1.8%465
14
Warfarin1.7%445
15
Aspirin1.6%416

Taken alongside

1
Aspirin25.3%6,430
2
Acetaminophen23.5%5,985
3
Atorvastatin-calcium21.9%5,558
4
Spironolactone20.8%5,295
5
Potassium-chloride19.1%4,858
6
Albuterol18.7%4,764
7
Levothyroxine-sodium18.2%4,619
8
Metoprolol17.9%4,552
9
Omeprazole17.1%4,346
10
Ergocalciferol16.6%4,229
11
Insulin15.0%3,816
12
Gabapentin14.7%3,739
13
Carvedilol13.0%3,312
14
Pantoprazole-sodium12.8%3,261
15
Allopurinol12.6%3,197

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports bumetanide side effects

51.8% of bumetanide adverse event reports involve female patients and 41.0% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.8%
Male41.0%
Unknown7.1%

Age group

< 20.4%
2–110.4%
12–170.2%
18–6435.7%
65+63.4%

What is bumetanide used for

Conditions and purposes for which patients were taking bumetanide when the adverse event was reported.

Abdominal DistensionAcute Kidney InjuryAcute Myocardial InfarctionAdverse EventAnaemiaAnalgesic TherapyAngina PectorisAngiopathyAnkle OedemaAnti-glomerular Basement Membrane DiseaseAnticoagulant TherapyAnxietyAortic Valve RepairArrhythmiaArteriosclerosis

Showing 15 of 331 indications

Bumetanide brand names and reporting trend

Bumetanide is sold under the brand name Enbumyst.

Brand names

Enbumyst20,461

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking bumetanide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.