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Buclizine Side Effects

The most commonly reported side effects of buclizine include anticholinergic syndrome, overdose, and drug abuse, based on 63 FDA adverse event reports from 2005 to 2025.

Buclizine side effects

Percentages show how often each reaction appears relative to total reports for buclizine.

1
Anticholinergic Syndrome17.5%11
2
Overdose15.9%10
3
Drug Abuse15.9%10
4
Acute Kidney Injury14.3%9
5
Dystonia14.3%9
6
Drug Interaction12.7%8
7
Pneumonia11.1%7
8
Speech Disorder9.5%6
9
Delirium9.5%6
10
Intentional Overdose9.5%6
11
Confusional State9.5%6
12
Depressed Level Of Consciousness7.9%5
13
Suicide Attempt6.3%4
14
Toxicity To Various Agents6.3%4
15
Bradypnoea6.3%4

These are voluntary reports and do not establish that buclizine caused these reactions.

Report severity

90.5%Serious57 reports
54.0%Hospitalizations34 reports
20.6%Fatal13 reports

Seriousness is determined by the reporter, not by OpenClaim.

Buclizine drug interactions

Other drugs that appear in adverse event reports alongside buclizine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ibuprofen19.0%12
2
Diphenhydramine19.0%12
3
Mirtazapine17.5%11
4
Amitriptyline-hydrochloride17.5%11
5
Hydroxyzine15.9%10
6
Alprazolam14.3%9
7
Topiramate14.3%9
8
Cyclobenzaprine-hydrochloride14.3%9
9
Quetiapine-fumarate12.7%8
10
Lithium12.7%8
11
Caffeine11.1%7
12
Fentanyl9.5%6
13
Risperidone9.5%6
14
Nicotine7.9%5
15
Quinine-sulfate6.3%4

Taken alongside

1
Acetaminophen17.5%11
2
Diphenhydramine11.1%7
3
Folic-acid9.5%6
4
Omeprazole9.5%6
5
Tramadol-hydrochloride9.5%6
6
Lactulose7.9%5
7
Pregabalin7.9%5
8
Simvastatin7.9%5
9
Prednisolone6.3%4
10
Levothyroxine-sodium6.3%4
11
Gabapentin6.3%4
12
Amlodipine6.3%4
13
Furosemide6.3%4
14
Losartan-potassium6.3%4
15
Enalapril-maleate4.8%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports buclizine side effects

50.8% of buclizine adverse event reports involve female patients and 36.5% involve male patients. The largest age group is adult at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.8%
Male36.5%
Unknown12.7%

Age group

< 20.0%
2–112.1%
12–172.1%
18–6472.3%
65+23.4%

What is buclizine used for

Conditions and purposes for which patients were taking buclizine when the adverse event was reported.

Antiallergic TherapyDecreased AppetiteDiabetes MellitusDecreased AppetiteDermatitis AtopicEczemaEczemaFolliculitisHypersensitivityIncreased AppetiteMultiple SclerosisMuscle Relaxant TherapyPainProduct Used For Unknown IndicationPruritus

Showing 15 of 19 indications

Buclizine brand names and reporting trend

Buclizine is sold under the brand name Bucladin-s.

Brand names

Bucladin-s66

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking buclizine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.