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Brodalumab Side Effects

The most commonly reported side effects of brodalumab include psoriasis, arthralgia, and fatigue, based on 1,892 FDA adverse event reports from 2013 to 2025. 12.2% of reports found the drug to be ineffective.

Brodalumab side effects

Percentages show how often each reaction appears relative to total reports for brodalumab.

1
Psoriasis24.9%471
2
Drug Ineffective12.2%230
3
Arthralgia9.6%181
4
Fatigue8.6%163
5
Psoriatic Arthropathy8.2%156
6
Intentional Product Use Issue7.7%146
7
Product Dose Omission Issue7.0%132
8
Disease Recurrence6.8%129
9
Headache6.7%126
10
Therapy Interrupted6.6%124
11
Off Label Use6.1%116
12
Inappropriate Schedule Of Product Administration6.1%115
13
Diarrhoea4.8%91
14
Pain In Extremity4.6%87
15
Covid-194.6%87

These are voluntary reports and do not establish that brodalumab caused these reactions.

Report severity

87.6%Serious1,657 reports
28.4%Hospitalizations537 reports
7.0%Fatal133 reports

Seriousness is determined by the reporter, not by OpenClaim.

Brodalumab drug interactions

Other drugs that appear in adverse event reports alongside brodalumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate9.0%171
2
Secukinumab8.5%161
3
Adalimumab8.3%157
4
Ustekinumab4.0%75
5
Risankizumab-rzaa3.9%73
6
Infliximab3.7%70
7
Etanercept3.3%62
8
Apremilast3.2%60
9
Ixekizumab2.9%55
10
Cyclosporine2.6%50
11
Guselkumab2.2%42
12
Certolizumab-pegol1.5%28
13
Acitretin1.5%28
14
Amoxicillin0.8%16
15
Betamethasone0.8%16

Taken alongside

1
Methotrexate5.0%94
2
Betamethasone4.5%85
3
Rosuvastatin4.5%85
4
Atorvastatin-calcium4.3%82
5
Metformin4.3%82
6
Aspirin4.1%77
7
Amlodipine4.0%75
8
Ergocalciferol3.9%74
9
Levothyroxine-sodium3.9%74
10
Folic-acid3.6%69
11
Pantoprazole-sodium3.4%65
12
Calcipotriene2.8%53
13
Acetaminophen2.5%47
14
Hydrochlorothiazide2.4%46
15
Clobetasol-propionate2.4%46

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports brodalumab side effects

44.0% of brodalumab adverse event reports involve female patients and 50.9% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.0%
Male50.9%
Unknown5.1%

Age group

< 20.0%
2–110.0%
12–170.1%
18–6466.4%
65+33.5%

What is brodalumab used for

Conditions and purposes for which patients were taking brodalumab when the adverse event was reported.

Ankylosing SpondylitisArthralgiaArthritisB-cell LymphomaBehcet^s SyndromeCoronary Artery DiseaseChronic Cutaneous Lupus ErythematosusChronic Spontaneous UrticariaCoeliac DiseaseColitis UlcerativeCrohn^s DiseaseDermatitis AtopicDiabetes MellitusErythrodermic PsoriasisEczema

Showing 15 of 45 indications

Brodalumab brand names and reporting trend

Brodalumab is sold under the brand name Siliq.

Brand names

Siliq1,069

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking brodalumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.