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Brivaracetam Side Effects

The most commonly reported side effects of brivaracetam include seizure, off label use, and fatigue, based on 8,121 FDA adverse event reports from 2004 to 2025. 11.1% of reports found the drug to be ineffective.

Brivaracetam side effects

Percentages show how often each reaction appears relative to total reports for brivaracetam.

1
Seizure36.4%2,954
2
Off Label Use12.8%1,041
3
Drug Ineffective11.1%899
4
Fatigue6.4%520
5
Somnolence5.5%447
6
Therapy Interrupted5.4%437
7
Overdose5.3%433
8
Dizziness5.3%432
9
Product Availability Issue4.2%344
10
Fall4.1%330
11
Generalised Tonic-clonic Seizure3.8%310
12
Aggression3.5%286
13
Headache3.4%277
14
Epilepsy3.4%277
15
Product Use Issue3.4%275

These are voluntary reports and do not establish that brivaracetam caused these reactions.

Report severity

80.7%Serious6,552 reports
27.2%Hospitalizations2,210 reports
5.2%Fatal420 reports

Seriousness is determined by the reporter, not by OpenClaim.

Brivaracetam drug interactions

Other drugs that appear in adverse event reports alongside brivaracetam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levetiracetam18.2%1,478
2
Lacosamide18.1%1,470
3
Lamotrigine7.3%595
4
Cenobamate5.7%465
5
Cannabidiol5.6%452
6
Clobazam5.3%430
7
Perampanel4.8%391
8
Topiramate4.1%333
9
Valproic-acid3.8%306
10
Midazolam3.4%280
11
Phenytoin3.3%264
12
Carbamazepine3.0%247
13
Zonisamide2.8%225
14
Valproate-sodium2.7%223
15
Oxcarbazepine2.6%208

Taken alongside

1
Lamotrigine9.9%805
2
Clobazam8.6%698
3
Lacosamide7.4%599
4
Clonazepam5.0%409
5
Levetiracetam4.3%349
6
Topiramate4.2%343
7
Perampanel3.7%303
8
Carbamazepine3.6%294
9
Zonisamide3.6%292
10
Oxcarbazepine3.5%288
11
Ergocalciferol3.2%263
12
Valproic-acid3.2%260
13
Midazolam3.2%256
14
Lorazepam3.0%243
15
Diazepam2.9%237

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports brivaracetam side effects

42.9% of brivaracetam adverse event reports involve female patients and 37.3% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.9%
Male37.3%
Unknown19.8%

Age group

< 21.6%
2–116.5%
12–175.7%
18–6470.8%
65+15.3%

What is brivaracetam used for

Conditions and purposes for which patients were taking brivaracetam when the adverse event was reported.

AnxietyAtonic SeizuresAuraAbnormal Weight GainAbortion ThreatenedAgitationAmnesiaAnticoagulant TherapyAntidepressant TherapyAnxietyAtonic SeizuresAtrial FibrillationAuraAutism Spectrum DisorderBaltic Myoclonic Epilepsy

Showing 15 of 142 indications

Brivaracetam brand names and reporting trend

Brivaracetam is sold under the brand name Briviact.

Brand names

Briviact5,984

Quarterly reports (20042025)

200520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking brivaracetam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.