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Brinzolamide Side Effects

The most commonly reported side effects of brinzolamide include treatment failure, eye pain, and dizziness, based on 12,614 FDA adverse event reports from 2004 to 2025. 6.5% of reports found the drug to be ineffective.

Brinzolamide side effects

Percentages show how often each reaction appears relative to total reports for brinzolamide.

1
Treatment Failure13.8%1,744
2
Drug Ineffective6.5%814
3
Eye Pain5.4%679
4
Dizziness5.0%629
5
Vision Blurred5.0%626
6
Dyspnoea4.9%612
7
Eye Irritation4.8%607
8
Fatigue4.7%598
9
Ocular Hyperaemia4.3%547
10
Diarrhoea4.2%524
11
Headache4.1%517
12
Fall3.9%488
13
Asthenia3.6%454
14
Intraocular Pressure Increased3.5%445
15
Malaise3.5%441

These are voluntary reports and do not establish that brinzolamide caused these reactions.

Report severity

54.9%Serious6,928 reports
18.9%Hospitalizations2,379 reports
6.2%Fatal782 reports

Seriousness is determined by the reporter, not by OpenClaim.

Brinzolamide drug interactions

Other drugs that appear in adverse event reports alongside brinzolamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Brimonidine-tartrate30.6%3,862
2
Latanoprost11.8%1,489
3
Timolol9.9%1,254
4
Travoprost9.0%1,139
5
Bimatoprost7.5%941
6
Dorzolamide-hydrochloride4.8%601
7
Atorvastatin-calcium3.7%470
8
Adalimumab3.5%441
9
Pregabalin3.2%398
10
Acetaminophen3.1%390
11
Omeprazole2.9%368
12
Tocilizumab2.8%347
13
Telmisartan2.7%344
14
Hydrochlorothiazide2.6%333
15
Etanercept2.6%328

Taken alongside

1
Brimonidine-tartrate17.1%2,155
2
Latanoprost11.8%1,488
3
Timolol9.8%1,232
4
Aspirin8.4%1,062
5
Acetaminophen7.9%998
6
Bimatoprost7.4%929
7
Atorvastatin-calcium6.9%875
8
Levothyroxine-sodium6.4%812
9
Furosemide6.2%776
10
Ergocalciferol6.0%753
11
Amlodipine5.9%744
12
Omeprazole5.7%717
13
Albuterol5.5%695
14
Travoprost4.6%585
15
Simvastatin4.6%574

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports brinzolamide side effects

53.9% of brinzolamide adverse event reports involve female patients and 35.3% involve male patients. The largest age group is elderly at 76%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.9%
Male35.3%
Unknown10.8%

Age group

< 20.4%
2–110.7%
12–170.4%
18–6422.3%
65+76.2%

What is brinzolamide used for

Conditions and purposes for which patients were taking brinzolamide when the adverse event was reported.

Abnormal Sensation In EyeAccidental Device Ingestion By A ChildAngle Closure GlaucomaAnterior Chamber Cleavage SyndromeAsthmaAdverse Drug ReactionAge-related Macular DegenerationAngle Closure GlaucomaAsthenopiaAstigmatismBehcet^s SyndromeBlindness UnilateralBlood PressureBlood Pressure Inadequately ControlledCataract

Showing 15 of 159 indications

Brinzolamide brand names and reporting trend

Brinzolamide is sold under the brand name Simbrinza.

Brand names

Simbrinza2,354

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking brinzolamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.