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Brincidofovir Side Effects

The most commonly reported side effects of brincidofovir include off label use, acute kidney injury, and adenovirus infection, based on 138 FDA adverse event reports from 2015 to 2025. 10.1% of reports found the drug to be ineffective.

Brincidofovir side effects

Percentages show how often each reaction appears relative to total reports for brincidofovir.

1
Off Label Use28.3%39
2
Acute Kidney Injury19.6%27
3
Adenovirus Infection10.9%15
4
Drug Ineffective10.1%14
5
Drug Resistance8.7%12
6
Hypotension8.0%11
7
Multiple Organ Dysfunction Syndrome8.0%11
8
Graft Versus Host Disease In Gastrointestinal Tract8.0%11
9
Immune Reconstitution Inflammatory Syndrome8.0%11
10
Condition Aggravated6.5%9
11
Respiratory Failure6.5%9
12
Cytomegalovirus Infection6.5%9
13
Pancytopenia6.5%9
14
Acute Graft Versus Host Disease In Skin5.8%8
15
Diarrhoea5.8%8

These are voluntary reports and do not establish that brincidofovir caused these reactions.

Report severity

81.9%Serious113 reports
29.0%Hospitalizations40 reports
42.0%Fatal58 reports

Seriousness is determined by the reporter, not by OpenClaim.

Brincidofovir drug interactions

Other drugs that appear in adverse event reports alongside brincidofovir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tacrolimus19.6%27
2
Foscarnet-sodium15.9%22
3
Mycophenolate15.2%21
4
Prednisolone11.6%16
5
Ganciclovir10.1%14
6
Cyclosporine10.1%14
7
Cidofovir8.7%12
8
Sulfamethoxazole8.0%11
9
Amphotericin-b8.0%11
10
Tecovirimat7.2%10
11
Trimethoprim6.5%9
12
Fludarabine-phosphate6.5%9
13
Prednisone5.8%8
14
Tobramycin5.8%8
15
Ruxolitinib5.8%8

Taken alongside

1
Cidofovir30.4%42
2
Tecovirimat19.6%27
3
Tacrolimus15.2%21
4
Acetaminophen13.0%18
5
Pantoprazole-sodium13.0%18
6
Furosemide12.3%17
7
Hydrocortisone12.3%17
8
Lorazepam11.6%16
9
Foscarnet-sodium11.6%16
10
Methylprednisolone10.9%15
11
Ondansetron10.9%15
12
Ganciclovir10.1%14
13
Vancomycin10.1%14
14
Amlodipine9.4%13
15
Prednisone8.7%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports brincidofovir side effects

29.7% of brincidofovir adverse event reports involve female patients and 60.1% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.7%
Male60.1%
Unknown10.1%

Age group

< 23.2%
2–1113.5%
12–1713.5%
18–6465.1%
65+4.8%

What is brincidofovir used for

Conditions and purposes for which patients were taking brincidofovir when the adverse event was reported.

Adenoviral Haemorrhagic CystitisAdenovirus EncephalomyeloradiculitisAdenovirus InfectionAcquired Immunodeficiency SyndromeAdenovirus InfectionCombined ImmunodeficiencyCytomegalovirus InfectionCytomegalovirus ViraemiaCow PoxCytomegalovirus InfectionCytomegalovirus ViraemiaDiffuse Large B-cell LymphomaEnterocolitisGenital HerpesHerpes Simplex

Showing 15 of 26 indications

Brincidofovir brand names and reporting trend

Brincidofovir is sold under the brand name Tembexa.

Brand names

Tembexa163

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking brincidofovir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.