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Brimonidine Side Effects

The most commonly reported side effects of brimonidine include treatment failure, eye irritation, and ocular hyperaemia, based on 34,700 FDA adverse event reports from 2004 to 2025. 7.5% of reports found the drug to be ineffective.

Brimonidine side effects

Percentages show how often each reaction appears relative to total reports for brimonidine.

1
Treatment Failure9.1%3,173
2
Drug Ineffective7.5%2,598
3
Eye Irritation6.1%2,114
4
Ocular Hyperaemia5.8%2,025
5
Eye Pain4.9%1,710
6
Vision Blurred4.1%1,440
7
Fatigue3.6%1,257
8
Headache3.6%1,234
9
Erythema3.4%1,184
10
Off Label Use3.4%1,173
11
Intraocular Pressure Increased3.1%1,062
12
Hypersensitivity3.0%1,037
13
Dizziness2.9%1,009
14
Condition Aggravated2.8%985
15
Visual Impairment2.5%878

These are voluntary reports and do not establish that brimonidine caused these reactions.

Report severity

38.9%Serious13,515 reports
14.7%Hospitalizations5,098 reports
3.9%Fatal1,355 reports

Seriousness is determined by the reporter, not by OpenClaim.

Brimonidine drug interactions

Other drugs that appear in adverse event reports alongside brimonidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Timolol17.2%5,962
2
Brinzolamide10.9%3,767
3
Latanoprost8.5%2,954
4
Bimatoprost6.0%2,067
5
Dorzolamide-hydrochloride4.8%1,676
6
Travoprost4.2%1,454
7
Lenalidomide3.0%1,045
8
Cenegermin-bkbj2.3%801
9
Adalimumab1.9%676
10
Dexamethasone0.9%314
11
Prednisolone0.8%280
12
Acetazolamide0.8%278
13
Dupilumab0.7%254
14
Netarsudil0.7%252
15
Pomalidomide0.7%246

Taken alongside

1
Timolol20.5%7,121
2
Latanoprost13.2%4,584
3
Aspirin10.8%3,732
4
Ergocalciferol9.2%3,178
5
Dorzolamide-hydrochloride9.0%3,130
6
Acetaminophen8.1%2,801
7
Atorvastatin-calcium8.0%2,774
8
Levothyroxine-sodium7.7%2,670
9
Amlodipine7.4%2,582
10
Bimatoprost7.0%2,426
11
Furosemide6.6%2,288
12
Brinzolamide6.4%2,226
13
Metoprolol6.1%2,114
14
Omeprazole5.9%2,057
15
Lisinopril5.5%1,895

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports brimonidine side effects

58.1% of brimonidine adverse event reports involve female patients and 34.6% involve male patients. The largest age group is elderly at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.1%
Male34.6%
Unknown7.2%

Age group

< 20.4%
2–110.4%
12–170.4%
18–6432.5%
65+66.3%

What is brimonidine used for

Conditions and purposes for which patients were taking brimonidine when the adverse event was reported.

Abnormal Sensation In EyeAccidental Device Ingestion By A ChildAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAcneAcute MyopiaAdverse EventAge-related Macular DegenerationAngle Closure GlaucomaAngular CheilitisAnterior Chamber Cleavage SyndromeAnterior Chamber DisorderAnxietyArthritis

Showing 15 of 418 indications

Brimonidine brand names and reporting trend

Brimonidine is sold under the brand name Qoliana.

Brand names

Qoliana23

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking brimonidine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.