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Brigatinib Side Effects

The most commonly reported side effects of brigatinib include death, non-small cell lung cancer, and off label use, based on 3,484 FDA adverse event reports from 2017 to 2025. 5.3% of reports found the drug to be ineffective.

#1 Reported: DeathAll side effects ↓Top Co-Medication: Alectinib-hydrochlorideDrug interactions ↓56% of Reports Are AdultDemographics ↓

Brigatinib side effects

Percentages show how often each reaction appears relative to total reports for brigatinib.

1
Death11.9%413
2
Non-small Cell Lung Cancer11.1%385
3
Off Label Use8.4%294
4
Diarrhoea7.1%248
5
Metastases To Central Nervous System6.8%236
6
Nausea6.5%227
7
Lung Neoplasm Malignant6.2%217
8
Blood Creatine Phosphokinase Increased6.2%215
9
Fatigue6.1%212
10
Product Dose Omission Issue5.7%199
11
Drug Ineffective5.3%183
12
Neoplasm Progression5.2%180
13
Vomiting3.7%128
14
Dyspnoea3.6%126
15
Rash3.5%123

These are voluntary reports and do not establish that brigatinib caused these reactions.

Report severity

88.9%Serious3,098 reports
27.2%Hospitalizations949 reports
21.7%Fatal757 reports

Seriousness is determined by the reporter, not by OpenClaim.

Brigatinib drug interactions

Other drugs that appear in adverse event reports alongside brigatinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Alectinib-hydrochloride4.7%164
2
Lorlatinib3.9%137
3
Pemetrexed2.4%85
4
Crizotinib2.0%69
5
Pembrolizumab1.8%62
6
Ceritinib1.5%52
7
Bevacizumab1.5%51
8
Gemcitabine1.4%50
9
Trastuzumab1.4%50
10
Oxaliplatin1.4%49
11
Carboplatin1.4%48
12
Capecitabine1.4%48
13
Docetaxel1.1%40
14
Paclitaxel1.1%39
15
Osimertinib-mesylate0.9%32

Taken alongside

1
Acetaminophen2.9%100
2
Ondansetron2.4%84
3
Levothyroxine-sodium2.3%81
4
Amlodipine2.3%80
5
Ergocalciferol2.2%76
6
Levetiracetam2.2%75
7
Dexamethasone2.1%73
8
Metformin1.9%65
9
Atorvastatin-calcium1.8%64
10
Pantoprazole-sodium1.8%62
11
Omeprazole1.6%57
12
Furosemide1.5%53
13
Gabapentin1.5%52
14
Apixaban1.5%52
15
Aspirin1.4%50

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports brigatinib side effects

48.5% of brigatinib adverse event reports involve female patients and 39.9% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.5%
Male39.9%
Unknown11.6%

Age group

< 20.0%
2–110.2%
12–170.5%
18–6456.2%
65+43.2%

What is brigatinib used for

Conditions and purposes for which patients were taking brigatinib when the adverse event was reported.

Acoustic NeuromaAdenocarcinomaAdenocarcinoma MetastaticAdrenal Gland CancerAlk Gene Rearrangement PositiveAnaplastic Large-cell LymphomaAnaplastic Lymphoma Kinase Gene MutationAcoustic NeuromaAdenocarcinomaAdenocarcinoma MetastaticAdrenal Gland CancerAnaplastic Large Cell Lymphoma T- And Null-cell TypesAnaplastic Large Cell Lymphoma T- And Null-cell Types RecurrentAnaplastic Large Cell Lymphoma T- And Null-cell Types RefractoryAnaplastic Large-cell Lymphoma

Showing 15 of 187 indications

Brigatinib brand names and reporting trend

Brigatinib is sold under the brand name Alunbrig.

Brand names

Alunbrig4,095

Quarterly reports (2017–2025)

201720182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking brigatinib with another medication?

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