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Brentuximab Side Effects

The most commonly reported side effects of brentuximab include off label use, febrile neutropenia, and pyrexia, based on 11,258 FDA adverse event reports from 2011 to 2025. 3.8% of reports found the drug to be ineffective.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: Doxorubicin-hydrochlorideDrug interactions ↓66% of Reports Are AdultDemographics ↓

Brentuximab side effects

Percentages show how often each reaction appears relative to total reports for brentuximab.

1
Off Label Use13.4%1,509
2
Febrile Neutropenia7.2%809
3
Pyrexia6.9%778
4
Neuropathy Peripheral6.7%758
5
Death6.0%681
6
Neutropenia5.6%633
7
Hodgkin^s Disease4.9%551
8
Diarrhoea3.9%441
9
Nausea3.8%433
10
Drug Ineffective3.8%429
11
Anaemia3.8%425
12
Thrombocytopenia3.8%424
13
Disease Progression3.4%388
14
Weight Decreased3.3%375
15
Pneumonia3.0%340

These are voluntary reports and do not establish that brentuximab caused these reactions.

Report severity

91.4%Serious10,290 reports
39.0%Hospitalizations4,396 reports
20.1%Fatal2,259 reports

Seriousness is determined by the reporter, not by OpenClaim.

Brentuximab drug interactions

Other drugs that appear in adverse event reports alongside brentuximab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Doxorubicin-hydrochloride32.5%3,659
2
Dacarbazine19.5%2,191
3
Cyclophosphamide18.7%2,107
4
Vinblastine-sulfate14.6%1,642
5
Etoposide13.9%1,567
6
Prednisone10.8%1,221
7
Dexamethasone9.3%1,044
8
Bendamustine-hydrochloride7.6%855
9
Vincristine-sulfate7.4%835
10
Cytarabine5.2%589
11
Gemcitabine5.2%587
12
Ifosfamide4.6%518
13
Prednisolone4.5%501
14
Rituximab4.2%470
15
Carboplatin4.2%469

Taken alongside

1
Doxorubicin-hydrochloride4.1%457
2
Sulfamethoxazole3.8%426
3
Acyclovir3.7%413
4
Ondansetron3.6%409
5
Acetaminophen3.6%406
6
Dexamethasone3.6%402
7
Prednisone3.1%346
8
Trimethoprim3.0%339
9
Cyclophosphamide2.7%300
10
Allopurinol2.6%293
11
Pantoprazole-sodium2.4%275
12
Omeprazole2.3%259
13
Dacarbazine2.1%237
14
Etoposide2.1%234
15
Vinblastine-sulfate1.9%211

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports brentuximab side effects

32.5% of brentuximab adverse event reports involve female patients and 45.0% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.5%
Male45.0%
Unknown22.5%

Age group

< 2<0.1%
2–111.1%
12–174.4%
18–6465.5%
65+28.9%

What is brentuximab used for

Conditions and purposes for which patients were taking brentuximab when the adverse event was reported.

Acute Graft Versus Host DiseaseAcute Myeloid LeukaemiaAdult T-cell Lymphoma/leukaemiaAdult T-cell Lymphoma/leukaemia RecurrentAdult T-cell Lymphoma/leukaemia Stage IvAlk Gene Rearrangement AssayAlk Gene Rearrangement PositiveAnaplastic Large Cell Lymphoma T- And Null-cell TypesAnaplastic Large Cell Lymphoma T- And Null-cell Types RecurrentAnaplastic Large Cell Lymphoma T- And Null-cell Types RefractoryAnaplastic Large Cell Lymphoma T- And Null-cell Types Stage IiiAnaplastic Large Cell Lymphoma T- And Null-cell Types Stage IvAnaplastic Large-cell LymphomaAnaplastic Large-cell Lymphoma, Primary Systemic TypeAngiocentric Lymphoma

Showing 15 of 361 indications

Brentuximab brand names and reporting trend

Brentuximab is sold under the brand name Adcetris.

Brand names

Adcetris7,023

Quarterly reports (2011–2025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking brentuximab with another medication?

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