OpenClaim

Bortezomib Side Effects

The most commonly reported side effects of bortezomib include plasma cell myeloma, off label use, and neuropathy peripheral, based on 87,654 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Bortezomib side effects

Percentages show how often each reaction appears relative to total reports for bortezomib.

1
Plasma Cell Myeloma10.2%8,982
2
Off Label Use6.9%6,091
3
Neuropathy Peripheral6.4%5,572
4
Diarrhoea5.0%4,346
5
Fatigue4.6%4,025
6
Drug Ineffective3.9%3,411
7
Pneumonia3.8%3,357
8
Death3.8%3,302
9
Thrombocytopenia3.3%2,933
10
Nausea2.9%2,532
11
Neutropenia2.7%2,337
12
Anaemia2.6%2,262
13
Rash2.5%2,202
14
Pyrexia2.5%2,192
15
Constipation2.1%1,843

These are voluntary reports and do not establish that bortezomib caused these reactions.

Report severity

83.8%Serious73,461 reports
32.2%Hospitalizations28,230 reports
15.8%Fatal13,855 reports

Seriousness is determined by the reporter, not by OpenClaim.

Bortezomib drug interactions

Other drugs that appear in adverse event reports alongside bortezomib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide40.4%35,399
2
Dexamethasone36.9%32,308
3
Daratumumab13.0%11,432
4
Cyclophosphamide12.5%10,914
5
Thalidomide8.0%6,969
6
Melphalan6.5%5,671
7
Doxorubicin-hydrochloride6.2%5,458
8
Pomalidomide6.1%5,366
9
Prednisone3.9%3,393
10
Rituximab3.3%2,915
11
Carfilzomib3.0%2,596
12
Etoposide2.8%2,417
13
Vincristine-sulfate2.1%1,845
14
Cisplatin2.1%1,830
15
Bendamustine-hydrochloride1.8%1,581

Taken alongside

1
Dexamethasone26.7%23,402
2
Acyclovir15.4%13,504
3
Aspirin12.0%10,488
4
Acetaminophen7.7%6,729
5
Zoledronic-acid6.4%5,625
6
Ondansetron5.9%5,175
7
Omeprazole5.7%5,026
8
Ergocalciferol5.1%4,472
9
Sulfamethoxazole4.4%3,868
10
Amlodipine4.4%3,866
11
Furosemide4.4%3,838
12
Oxycodone4.2%3,642
13
Trimethoprim4.0%3,530
14
Pantoprazole-sodium4.0%3,493
15
Gabapentin3.8%3,327

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports bortezomib side effects

36.5% of bortezomib adverse event reports involve female patients and 45.2% involve male patients. The largest age group is elderly at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.5%
Male45.2%
Unknown18.3%

Age group

< 20.3%
2–110.9%
12–170.7%
18–6442.6%
65+55.5%

What is bortezomib used for

Conditions and purposes for which patients were taking bortezomib when the adverse event was reported.

Abdominal PainAccidentAccidental ExposureAccidental Exposure To ProductAcquired HaemophiliaAcquired Von Willebrand^s DiseaseActinic KeratosisActinomycosisAcute Graft Versus Host DiseaseAcute Kidney InjuryAcute LeukaemiaAcute Leukaemia In RemissionAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Lymphocytic Leukaemia Refractory

Showing 15 of 877 indications

Bortezomib brand names and reporting trend

Bortezomib is sold under the brand name Velcade.

Brand names

Velcade40,679

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking bortezomib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.