The most commonly reported side effects of biperiden include drug interaction, neuroleptic malignant syndrome, and tremor, based on 6,798 FDA adverse event reports from 2004 to 2025. 3.7% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for biperiden.
1
Drug Interaction6.4%432
2
Neuroleptic Malignant Syndrome4.2%285
3
Tremor4.1%282
4
Off Label Use3.9%267
5
Somnolence3.9%262
6
Drug Ineffective3.7%250
7
Pyrexia3.5%241
8
Intentional Overdose3.5%236
9
Suicide Attempt3.5%236
10
Toxicity To Various Agents3.4%229
11
Extrapyramidal Disorder3.0%203
12
Confusional State2.8%192
13
Dyskinesia2.8%192
14
Drug Abuse2.7%183
15
Weight Increased2.6%175
These are voluntary reports and do not establish that biperiden caused these reactions.
Report severity
98.3%Serious6,684 reports
56.8%Hospitalizations3,864 reports
11.1%Fatal754 reports
Seriousness is determined by the reporter, not by OpenClaim.
Biperiden drug interactions
Other drugs that appear in adverse event reports alongside biperiden. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
1
Risperidone20.2%1,376
2
Olanzapine15.5%1,054
3
Haloperidol15.1%1,029
4
Quetiapine-fumarate14.3%972
5
Aripiprazole14.3%970
6
Clozapine9.1%616
7
Lorazepam7.1%485
8
Diazepam5.0%340
9
Paliperidone4.7%321
10
Sertraline-hydrochloride3.3%224
11
Mirtazapine2.9%196
12
Lamotrigine2.9%195
13
Valproic-acid2.7%182
14
Clonazepam2.6%176
15
Carbamazepine2.5%172
Taken alongside
1
Risperidone8.7%590
2
Lorazepam8.1%549
3
Haloperidol7.9%539
4
Quetiapine-fumarate5.3%363
5
Olanzapine4.8%327
6
Diazepam4.8%326
7
Aripiprazole4.1%277
8
Valproic-acid4.0%273
9
Clonazepam3.3%225
10
Lithium2.8%191
11
Carbamazepine2.6%175
12
Levomepromazine2.4%163
13
Levothyroxine-sodium2.2%151
14
Valproate-sodium2.2%150
15
Eszopiclone2.1%144
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
Who reports biperiden side effects
46.7% of biperiden adverse event reports involve female patients and 47.0% involve male patients. The largest age group is adult at 76%. These figures reflect who reports side effects, not underlying risk.
Sex
Female46.7%
Male47.0%
Unknown6.2%
Age group
< 21.0%
2–110.6%
12–172.9%
18–6475.7%
65+19.7%
What is biperiden used for
Conditions and purposes for which patients were taking biperiden when the adverse event was reported.
