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Binimetinib Side Effects

The most commonly reported side effects of binimetinib include off label use, death, and nausea, based on 7,391 FDA adverse event reports from 2016 to 2025.

Binimetinib side effects

Percentages show how often each reaction appears relative to total reports for binimetinib.

1
Off Label Use12.9%950
2
Death10.5%773
3
Nausea9.3%688
4
Fatigue7.9%585
5
Diarrhoea7.4%548
6
Product Use In Unapproved Indication7.0%520
7
Pyrexia7.0%520
8
Neoplasm Progression5.3%393
9
Vomiting5.3%390
10
Rash5.2%381
11
Serous Retinal Detachment4.4%324
12
Malaise2.9%217
13
Arthralgia2.9%214
14
Decreased Appetite2.8%207
15
Vision Blurred2.8%204

These are voluntary reports and do not establish that binimetinib caused these reactions.

Report severity

68.8%Serious5,083 reports
28.8%Hospitalizations2,127 reports
15.6%Fatal1,155 reports

Seriousness is determined by the reporter, not by OpenClaim.

Binimetinib drug interactions

Other drugs that appear in adverse event reports alongside binimetinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Encorafenib87.2%6,448
2
Nivolumab6.1%449
3
Cetuximab4.3%318
4
Ipilimumab4.3%317
5
Pembrolizumab1.8%134
6
Trametinib1.7%127
7
Dabrafenib-mesylate1.6%118
8
Vemurafenib0.8%60
9
Fluorouracil0.7%50
10
Cobimetinib-fumarate0.7%50
11
Bevacizumab0.6%44
12
Palbociclib0.5%39
13
Oxaliplatin0.5%38
14
Irinotecan-hydrochloride0.4%33
15
Oxycodone0.4%29

Taken alongside

1
Levothyroxine-sodium5.7%422
2
Acetaminophen5.7%418
3
Ondansetron4.9%363
4
Cetuximab4.4%328
5
Pantoprazole-sodium4.1%302
6
Amlodipine3.9%289
7
Omeprazole3.6%267
8
Dexamethasone3.6%267
9
Ergocalciferol3.2%239
10
Atorvastatin-calcium3.1%231
11
Prednisone3.1%230
12
Oxycodone3.1%228
13
Aspirin3.0%225
14
Encorafenib3.0%221
15
Levetiracetam2.8%210

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports binimetinib side effects

32.5% of binimetinib adverse event reports involve female patients and 36.6% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.5%
Male36.6%
Unknown30.9%

Age group

< 2<0.1%
2–110.6%
12–170.3%
18–6448.6%
65+50.5%

What is binimetinib used for

Conditions and purposes for which patients were taking binimetinib when the adverse event was reported.

Acute Myeloid LeukaemiaAddison^s DiseaseAdenocarcinomaAdenocarcinoma Of ColonAdrenal Gland CancerAmeloblastic CarcinomaAnaemiaAnaemia Vitamin B12 DeficiencyAnal CancerAppendix CancerAstrocytomaAstrocytoma MalignantAsymptomatic Hiv InfectionAutoimmune HepatitisAcral Lentiginous Melanoma

Showing 15 of 316 indications

Binimetinib brand names and reporting trend

Binimetinib is sold under the brand name Mektovi.

Brand names

Mektovi2,188

Quarterly reports (20162025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking binimetinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.