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Bictegravir Side Effects

The most commonly reported side effects of bictegravir include bone density decreased, chronic kidney disease, and bone loss, based on 17,632 FDA adverse event reports from 2017 to 2025.

Bictegravir side effects

Percentages show how often each reaction appears relative to total reports for bictegravir.

1
Bone Density Decreased37.1%6,536
2
Chronic Kidney Disease20.4%3,596
3
Bone Loss19.5%3,432
4
Tooth Loss19.1%3,376
5
Osteonecrosis19.0%3,355
6
Multiple Fractures17.7%3,122
7
Renal Failure16.9%2,983
8
Osteoporosis15.6%2,751
9
Pain14.4%2,533
10
Renal Injury14.1%2,481
11
Emotional Distress13.8%2,426
12
Anxiety12.9%2,267
13
Anhedonia12.2%2,145
14
Skeletal Injury12.0%2,115
15
Osteopenia10.5%1,854

These are voluntary reports and do not establish that bictegravir caused these reactions.

Report severity

73.5%Serious12,966 reports
12.1%Hospitalizations2,141 reports
4.0%Fatal700 reports

Seriousness is determined by the reporter, not by OpenClaim.

Bictegravir drug interactions

Other drugs that appear in adverse event reports alongside bictegravir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tenofovir89.2%15,720
2
Emtricitabine87.9%15,507
3
Efavirenz26.3%4,630
4
Cobicistat14.0%2,473
5
Elvitegravir13.9%2,448
6
Rilpivirine12.1%2,138
7
Cabotegravir2.7%474
8
Dolutegravir2.4%431
9
Lamivudine1.5%271
10
Ritonavir1.0%177
11
Abacavir0.8%148
12
Darunavir0.8%135
13
Treprostinil0.7%120
14
Raltegravir-potassium0.6%107
15
Lopinavir0.5%89

Taken alongside

1
Tenofovir63.6%11,208
2
Emtricitabine63.5%11,202
3
Cobicistat15.7%2,761
4
Elvitegravir13.4%2,360
5
Rilpivirine4.2%735
6
Darunavir3.8%663
7
Lamivudine3.4%596
8
Dolutegravir3.2%568
9
Ergocalciferol3.2%563
10
Atorvastatin-calcium3.0%535
11
Acetaminophen2.9%507
12
Ritonavir2.8%501
13
Albuterol2.7%476
14
Omeprazole2.5%444
15
Gabapentin2.4%427

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports bictegravir side effects

24.7% of bictegravir adverse event reports involve female patients and 69.4% involve male patients. The largest age group is adult at 92%. These figures reflect who reports side effects, not underlying risk.

Sex

Female24.7%
Male69.4%
Unknown5.9%

Age group

< 20.2%
2–110.1%
12–170.3%
18–6491.6%
65+7.7%

What is bictegravir used for

Conditions and purposes for which patients were taking bictegravir when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hiv InfectionAids RetinopathyAntiretroviral TherapyAntiviral TreatmentAsymptomatic Hiv InfectionAccident At WorkAcquired Immunodeficiency SyndromeAcute Hiv InfectionAdult T-cell Lymphoma/leukaemiaAdverse Drug ReactionAlopecia TotalisAntifungal ProphylaxisAntiretroviral TherapyAntiviral Treatment

Showing 15 of 113 indications

Bictegravir brand names and reporting trend

Bictegravir is sold under brand names including Bictegravir, Emtricitabine And Tenofovir Alafenamide, Biktarvy.

Brand names

Bictegravir, Emtricitabine And Tenofovir Alafenamide294
Biktarvy6

Quarterly reports (20172025)

201720182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking bictegravir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.