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Bezlotoxumab Side Effects

The most commonly reported side effects of bezlotoxumab include clostridium difficile infection, treatment failure, and diarrhoea, based on 347 FDA adverse event reports from 2008 to 2025. 20.2% of reports found the drug to be ineffective.

Bezlotoxumab side effects

Percentages show how often each reaction appears relative to total reports for bezlotoxumab.

1
Clostridium Difficile Infection37.2%129
2
Drug Ineffective20.2%70
3
Treatment Failure12.4%43
4
Diarrhoea8.4%29
5
Clostridium Difficile Colitis6.1%21
6
Death5.5%19
7
Pyrexia5.2%18
8
Clostridium Test Positive4.6%16
9
Nausea4.6%16
10
Product Use In Unapproved Indication3.7%13
11
Vomiting3.7%13
12
Avian Influenza3.7%13
13
Renal Graft Infection3.7%13
14
Adenovirus Infection3.7%13
15
Urinary Tract Infection Pseudomonal3.7%13

These are voluntary reports and do not establish that bezlotoxumab caused these reactions.

Report severity

77.5%Serious269 reports
31.1%Hospitalizations108 reports
18.2%Fatal63 reports

Seriousness is determined by the reporter, not by OpenClaim.

Bezlotoxumab drug interactions

Other drugs that appear in adverse event reports alongside bezlotoxumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Fidaxomicin28.2%98
2
Vancomycin28.2%98
3
Metronidazole4.6%16
4
Tacrolimus4.6%16
5
Sirolimus4.0%14
6
Prednisone4.0%14
7
Omeprazole3.7%13
8
Ertapenem-sodium3.5%12
9
Adalimumab3.2%11
10
Trastuzumab2.0%7
11
Ganciclovir1.4%5
12
Ciprofloxacin1.2%4
13
Rifaximin1.2%4
14
Denosumab0.9%3
15
Ribociclib0.9%3

Taken alongside

1
Vancomycin18.2%63
2
Fidaxomicin8.4%29
3
Furosemide4.6%16
4
Acetaminophen4.6%16
5
Metronidazole4.6%16
6
Aspirin2.6%9
7
Prednisone2.6%9
8
Ondansetron2.3%8
9
Insulin2.3%8
10
Pantoprazole-sodium2.3%8
11
Methylprednisolone2.0%7
12
Sertraline-hydrochloride2.0%7
13
Levothyroxine-sodium1.7%6
14
Omeprazole1.7%6
15
Gabapentin1.7%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports bezlotoxumab side effects

61.4% of bezlotoxumab adverse event reports involve female patients and 28.5% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female61.4%
Male28.5%
Unknown10.1%

Age group

< 20.0%
2–110.0%
12–170.4%
18–6442.3%
65+57.3%

What is bezlotoxumab used for

Conditions and purposes for which patients were taking bezlotoxumab when the adverse event was reported.

Antibiotic ProphylaxisClostridial InfectionClostridium Difficile ColitisClostridium Difficile ImmunisationClostridium Difficile InfectionClostridial InfectionClostridium Difficile ColitisClostridium Difficile InfectionEnterocolitis BacterialEnterocolitisGastrointestinal Disorder ProphylaxisInfection ProphylaxisInfection ProphylaxisProduct Used For Unknown IndicationProphylaxis

Showing 15 of 18 indications

Bezlotoxumab brand names and reporting trend

Bezlotoxumab is sold under the brand name Zinplava.

Brand names

Zinplava56

Quarterly reports (20082025)

200820202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking bezlotoxumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.