OpenClaim

Bevacizumab Side Effects

The most commonly reported side effects of bevacizumab include off label use, death, and disease progression, based on 127,391 FDA adverse event reports from 2004 to 2025. 2.4% of reports found the drug to be ineffective.

Bevacizumab side effects

Percentages show how often each reaction appears relative to total reports for bevacizumab.

1
Off Label Use11.1%14,159
2
Death9.4%12,026
3
Disease Progression5.1%6,468
4
Diarrhoea4.9%6,192
5
Fatigue4.6%5,835
6
Nausea4.4%5,640
7
Hypertension4.1%5,285
8
Vomiting3.2%4,105
9
Anaemia3.0%3,813
10
Neutropenia2.8%3,546
11
Pyrexia2.5%3,217
12
Decreased Appetite2.5%3,156
13
Asthenia2.5%3,147
14
Drug Ineffective2.4%3,079
15
Thrombocytopenia2.3%2,949

These are voluntary reports and do not establish that bevacizumab caused these reactions.

Report severity

88.9%Serious113,189 reports
32.6%Hospitalizations41,529 reports
22.3%Fatal28,397 reports

Seriousness is determined by the reporter, not by OpenClaim.

Bevacizumab drug interactions

Other drugs that appear in adverse event reports alongside bevacizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxaliplatin11.4%14,505
2
Fluorouracil10.7%13,671
3
Atezolizumab10.6%13,507
4
Paclitaxel10.3%13,184
5
Carboplatin9.8%12,429
6
Capecitabine8.8%11,231
7
Irinotecan-hydrochloride8.2%10,452
8
Pemetrexed3.0%3,859
9
Erlotinib-hydrochloride2.9%3,665
10
Cisplatin2.6%3,349
11
Levoleucovorin2.5%3,177
12
Gemcitabine2.3%2,967
13
Docetaxel2.1%2,690
14
Leucovorin-calcium2.1%2,680
15
Doxorubicin-hydrochloride2.0%2,589

Taken alongside

1
Dexamethasone6.5%8,341
2
Paclitaxel4.7%6,044
3
Fluorouracil4.4%5,609
4
Carboplatin4.2%5,408
5
Acetaminophen4.1%5,205
6
Ondansetron3.8%4,885
7
Oxaliplatin3.5%4,518
8
Irinotecan-hydrochloride3.3%4,149
9
Amlodipine2.6%3,302
10
Omeprazole2.3%2,978
11
Aspirin2.1%2,674
12
Pantoprazole-sodium2.0%2,561
13
Oxycodone2.0%2,561
14
Levothyroxine-sodium1.9%2,360
15
Lorazepam1.8%2,282

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports bevacizumab side effects

44.0% of bevacizumab adverse event reports involve female patients and 37.3% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.0%
Male37.3%
Unknown18.7%

Age group

< 20.5%
2–111.1%
12–170.7%
18–6452.8%
65+45.0%

What is bevacizumab used for

Conditions and purposes for which patients were taking bevacizumab when the adverse event was reported.

Abdominal LymphadenopathyAbdominal NeoplasmAcinar Cell Carcinoma Of PancreasAcoustic NeuromaAcral Lentiginous Melanoma Stage IvActh-producing Pituitary TumourAcute Coronary SyndromeAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia (in Remission)Acute Respiratory FailureAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma Of Appendix

Showing 15 of 2,096 indications

Bevacizumab brand names and reporting trend

Bevacizumab is sold under several brand names including Avastin, Vegzelma, Mvasi.

Brand names

Avastin75,927
Vegzelma79
Mvasi26
Zirabev18
Alymsys4

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking bevacizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.