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Benzylpenicilloyl Side Effects

The most commonly reported side effects of benzylpenicilloyl include fatigue, headache, and diarrhoea, based on 3,347 FDA adverse event reports from 2004 to 2025. 5.3% of reports found the drug to be ineffective.

Benzylpenicilloyl side effects

Percentages show how often each reaction appears relative to total reports for benzylpenicilloyl.

1
Fatigue9.9%333
2
Headache7.4%247
3
Diarrhoea7.2%240
4
Nausea6.3%212
5
Pain6.0%200
6
Dizziness5.6%189
7
Drug Ineffective5.3%176
8
Arthralgia4.8%162
9
Off Label Use4.5%149
10
Rash4.3%145
11
Pruritus3.8%127
12
Asthenia3.7%123
13
Dyspnoea3.6%121
14
Vomiting3.6%120
15
Fall3.5%116

These are voluntary reports and do not establish that benzylpenicilloyl caused these reactions.

Report severity

52.3%Serious1,749 reports
20.9%Hospitalizations698 reports
4.5%Fatal150 reports

Seriousness is determined by the reporter, not by OpenClaim.

Benzylpenicilloyl drug interactions

Other drugs that appear in adverse event reports alongside benzylpenicilloyl. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate7.9%264
2
Lenalidomide5.1%172
3
Adalimumab5.0%167
4
Dupilumab3.4%115
5
Etanercept2.4%81
6
Tofacitinib2.1%70
7
Cenegermin-bkbj2.0%68
8
Rituximab1.9%62
9
Naproxen1.6%55
10
Everolimus1.6%53
11
Ruxolitinib1.6%53
12
Dimethyl1.6%52
13
Apremilast1.6%52
14
Methotrexate1.6%52
15
Prednisone1.5%51

Taken alongside

1
Ergocalciferol41.9%1,403
2
Ascorbic-acid24.9%835
3
Calcium21.8%728
4
Acetaminophen20.7%693
5
Aspirin20.7%692
6
Levothyroxine-sodium19.0%637
7
Fish16.1%538
8
Cyanocobalamin15.5%518
9
Magnesium-acetate-tetrahydrate14.1%471
10
Omeprazole14.0%470
11
Albuterol12.6%423
12
Fluticasone12.6%421
13
Gabapentin12.5%419
14
Acyclovir10.4%348
15
Folic-acid10.3%345

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports benzylpenicilloyl side effects

71.1% of benzylpenicilloyl adverse event reports involve female patients and 22.8% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.1%
Male22.8%
Unknown6.1%

Age group

< 20.2%
2–110.9%
12–170.8%
18–6456.4%
65+41.7%

What is benzylpenicilloyl used for

Conditions and purposes for which patients were taking benzylpenicilloyl when the adverse event was reported.

Abdominal DiscomfortAllergy TestAlopeciaAmino Acid Level AbnormalAntiviral ProphylaxisAnxietyAphthous StomatitisAphthous UlcerArthritisAtaxiaAutoimmune DisorderAllergy TestAnaemiaAnosmiaAntiviral Prophylaxis

Showing 15 of 110 indications

Benzylpenicilloyl brand names and reporting trend

Benzylpenicilloyl is sold under the brand name Pre-pen.

Brand names

Pre-pen3,382

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking benzylpenicilloyl with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.