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Benznidazole Side Effects

The most commonly reported side effects of benznidazole include product use issue, rash, and intentional product use issue, based on 94 FDA adverse event reports from 2006 to 2025. 8.5% of reports found the drug to be ineffective.

Benznidazole side effects

Percentages show how often each reaction appears relative to total reports for benznidazole.

1
Product Use Issue21.3%20
2
Rash19.1%18
3
Intentional Product Use Issue18.1%17
4
American Trypanosomiasis10.6%10
5
Drug Ineffective8.5%8
6
Headache8.5%8
7
Nausea8.5%8
8
Drug Interaction6.4%6
9
Off Label Use5.3%5
10
Pruritus5.3%5
11
Hepatotoxicity5.3%5
12
Dizziness5.3%5
13
Pyrexia4.3%4
14
Vomiting4.3%4
15
Rash Pruritic4.3%4

These are voluntary reports and do not establish that benznidazole caused these reactions.

Report severity

54.3%Serious51 reports
21.3%Hospitalizations20 reports
7.4%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Benznidazole drug interactions

Other drugs that appear in adverse event reports alongside benznidazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Mycophenolate9.6%9
2
Tacrolimus8.5%8
3
Prednisone8.5%8
4
Cyclosporine7.4%7
5
Treprostinil7.4%7
6
Metronidazole5.3%5
7
Posaconazole4.3%4
8
Basiliximab4.3%4
9
Cetirizine-hydrochloride4.3%4
10
Methylprednisolone3.2%3
11
Rituximab3.2%3
12
Gabapentin2.1%2
13
Azathioprine2.1%2
14
Prednisolone2.1%2
15
Valproic-acid2.1%2

Taken alongside

1
Atorvastatin-calcium13.8%13
2
Aspirin10.6%10
3
Ganciclovir9.6%9
4
Amlodipine8.5%8
5
Mycophenolate8.5%8
6
Fluticasone8.5%8
7
Prednisone7.4%7
8
Metformin7.4%7
9
Pantoprazole-sodium7.4%7
10
Albuterol7.4%7
11
Gabapentin7.4%7
12
Digoxin7.4%7
13
Acetaminophen6.4%6
14
Potassium-chloride6.4%6
15
Sodium-chloride6.4%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports benznidazole side effects

50.0% of benznidazole adverse event reports involve female patients and 33.0% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.0%
Male33.0%
Unknown17.0%

Age group

< 20.0%
2–113.2%
12–171.6%
18–6485.7%
65+9.5%

What is benznidazole used for

Conditions and purposes for which patients were taking benznidazole when the adverse event was reported.

American TrypanosomiasisAmerican TrypanosomiasisArthropod BiteBacterial InfectionChagas^ CardiomyopathyCardiac AneurysmCardiomyopathyCentral Nervous System InfectionChagas^ CardiomyopathyEnterobiasisEvidence Based TreatmentImmunosuppressionInfection ReactivationInfection ReactivationMeningoencephalitis Amoebic

Showing 15 of 20 indications

Benznidazole brand names and reporting trend

Benznidazole is sold under the brand name Benznidazole.

Brand names

Benznidazole105

Quarterly reports (20062025)

200620202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking benznidazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.