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Benzhydrocodone Side Effects

The most commonly reported side effects of benzhydrocodone include chronic kidney disease, renal failure, and acute kidney injury, based on 136 FDA adverse event reports from 2005 to 2024. 3.7% of reports found the drug to be ineffective.

Benzhydrocodone side effects

Percentages show how often each reaction appears relative to total reports for benzhydrocodone.

1
Chronic Kidney Disease34.6%47
2
Renal Failure24.3%33
3
Acute Kidney Injury21.3%29
4
Renal Injury13.2%18
5
End Stage Renal Disease12.5%17
6
Rebound Acid Hypersecretion6.6%9
7
Tubulointerstitial Nephritis5.9%8
8
Drug Ineffective3.7%5
9
Depression3.7%5
10
Dyspnoea3.7%5
11
Product Use In Unapproved Indication3.7%5
12
Nephrogenic Anaemia3.7%5
13
Gastrooesophageal Reflux Disease3.7%5
14
Drug Dose Omission2.9%4
15
Anxiety2.9%4

These are voluntary reports and do not establish that benzhydrocodone caused these reactions.

Report severity

81.6%Serious111 reports
33.1%Hospitalizations45 reports
8.8%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Benzhydrocodone drug interactions

Other drugs that appear in adverse event reports alongside benzhydrocodone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Esomeprazole37.5%51
2
Omeprazole31.6%43
3
Pantoprazole-sodium22.1%30
4
Lansoprazole17.6%24
5
Dexlansoprazole11.0%15
6
Quetiapine-fumarate4.4%6
7
Adalimumab2.9%4
8
Pembrolizumab2.9%4
9
Lenalidomide2.9%4
10
Naproxen2.2%3
11
Dabigatran-etexilate-mesylate2.2%3
12
Exenatide-synthetic2.2%3
13
Rabeprazole-sodium2.2%3
14
Gabapentin1.5%2
15
Lisinopril1.5%2

Taken alongside

1
Furosemide30.9%42
2
Insulin25.7%35
3
Acetaminophen25.0%34
4
Gabapentin23.5%32
5
Aspirin19.9%27
6
Atorvastatin-calcium19.1%26
7
Lisinopril19.1%26
8
Amlodipine19.1%26
9
Levothyroxine-sodium19.1%26
10
Metformin18.4%25
11
Albuterol17.6%24
12
Tramadol-hydrochloride17.6%24
13
Ergocalciferol17.6%24
14
Prednisone16.9%23
15
Alprazolam16.9%23

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports benzhydrocodone side effects

71.3% of benzhydrocodone adverse event reports involve female patients and 25.0% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.3%
Male25.0%
Unknown3.7%

Age group

< 20.0%
2–110.0%
12–171.0%
18–6469.6%
65+29.4%

What is benzhydrocodone used for

Conditions and purposes for which patients were taking benzhydrocodone when the adverse event was reported.

Back PainBrain InjuryCancer PainChest PainConstipationMyalgiaOsteoarthritisPainPain ManagementPalmar-plantar Erythrodysaesthesia SyndromeProduct Used For Unknown IndicationProduct Used For Unknown Indication

Benzhydrocodone brand names and reporting trend

Benzhydrocodone is sold under the brand name Apadaz.

Brand names

Apadaz140

Quarterly reports (20052024)

200520202024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking benzhydrocodone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.