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Benoxinate Side Effects

The most commonly reported side effects of benoxinate include toxic anterior segment syndrome, aqueous fibrin, and inflammation, based on 164 FDA adverse event reports from 2004 to 2025.

Benoxinate side effects

Percentages show how often each reaction appears relative to total reports for benoxinate.

1
Toxic Anterior Segment Syndrome15.9%26
2
Aqueous Fibrin11.6%19
3
Inflammation9.8%16
4
Non-infectious Endophthalmitis7.9%13
5
Conjunctivitis7.9%13
6
Off Label Use6.7%11
7
Corneal Disorder6.1%10
8
Vision Blurred6.1%10
9
Vitritis6.1%10
10
Hypopyon6.1%10
11
Dyspnoea5.5%9
12
Headache4.9%8
13
Fatigue4.3%7
14
Eye Pain4.3%7
15
Urticaria3.7%6

These are voluntary reports and do not establish that benoxinate caused these reactions.

Report severity

90.2%Serious148 reports
17.7%Hospitalizations29 reports
7.9%Fatal13 reports

Seriousness is determined by the reporter, not by OpenClaim.

Benoxinate drug interactions

Other drugs that appear in adverse event reports alongside benoxinate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone18.3%30
2
Povidone-iodine17.7%29
3
Magnesium-chloride17.7%29
4
Tobramycin17.7%29
5
Calcium-chloride17.1%28
6
Potassium-chloride17.1%28
7
Sodium-acetate17.1%28
8
Sodium-chloride17.1%28
9
Sodium-citrate17.1%28
10
Tropicamide13.4%22
11
Lidocaine12.2%20
12
Tetracaine11.0%18
13
Aflibercept10.4%17
14
Phenylephrine9.8%16
15
Triamcinolone8.5%14

Taken alongside

1
Povidone-iodine20.1%33
2
Lidocaine7.3%12
3
Tropicamide7.3%12
4
Fluorescein-sodium6.1%10
5
Ofloxacin6.1%10
6
Levofloxacin4.9%8
7
Dexamethasone4.9%8
8
Atorvastatin-calcium4.3%7
9
Tobramycin4.3%7
10
Amlodipine4.3%7
11
Aspirin4.3%7
12
Acetaminophen4.3%7
13
Prednisone4.3%7
14
Omeprazole4.3%7
15
Insulin3.7%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports benoxinate side effects

43.3% of benoxinate adverse event reports involve female patients and 26.2% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.3%
Male26.2%
Unknown30.5%

Age group

< 22.1%
2–110.0%
12–170.0%
18–6438.1%
65+59.8%

What is benoxinate used for

Conditions and purposes for which patients were taking benoxinate when the adverse event was reported.

AnaesthesiaAnaesthesia ProcedureAnaesthesiaAnaesthesia EyeAnaesthesia ProcedureAnaesthetic Ophthalmic ProcedureAnalgesic TherapyBiopsy EyelidCataractColonoscopyDiagnostic ProcedureDrug Use For Unknown IndicationEye IrrigationFlatulenceHaemorrhoids

Showing 15 of 33 indications

Benoxinate brand names and reporting trend

Benoxinate is sold under the brand name Fluorescein Sodium And Benoxinate Hydrochloride.

Brand names

Fluorescein Sodium And Benoxinate Hydrochloride13

Quarterly reports (20042025)

200420152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking benoxinate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.