OpenClaim

Bempedoic Side Effects

The most commonly reported side effects of bempedoic include myalgia, arthralgia, and muscle spasms, based on 2,927 FDA adverse event reports from 2004 to 2025. 2.6% of reports found the drug to be ineffective.

Bempedoic side effects

Percentages show how often each reaction appears relative to total reports for bempedoic.

1
Myalgia13.8%405
2
Arthralgia9.1%266
3
Muscle Spasms6.4%186
4
Pain In Extremity6.1%180
5
Nausea5.5%162
6
Dizziness5.4%159
7
Fatigue5.4%157
8
Headache4.9%142
9
Diarrhoea4.4%129
10
Dyspnoea3.5%102
11
Pain3.4%100
12
Back Pain3.1%92
13
Rash3.1%90
14
Blood Creatine Phosphokinase Increased3.0%88
15
Muscular Weakness2.8%83

These are voluntary reports and do not establish that bempedoic caused these reactions.

Report severity

52.5%Serious1,536 reports
13.0%Hospitalizations380 reports
1.2%Fatal34 reports

Seriousness is determined by the reporter, not by OpenClaim.

Bempedoic drug interactions

Other drugs that appear in adverse event reports alongside bempedoic. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ezetimibe33.4%979
2
Rosuvastatin7.8%227
3
Atorvastatin-calcium6.6%194
4
Simvastatin4.7%138
5
Evolocumab4.0%117
6
Pravastatin-sodium1.7%51
7
Alirocumab1.4%41
8
Gemfibrozil1.3%39
9
Fluvastatin-sodium1.3%38
10
Inclisiran-sodium1.1%33
11
Dupilumab1.0%29
12
Apixaban0.9%27
13
Bisoprolol-fumarate0.6%17
14
Metoprolol0.5%15
15
Aspirin0.5%15

Taken alongside

1
Aspirin13.3%388
2
Ezetimibe13.2%387
3
Amlodipine6.9%201
4
Levothyroxine-sodium6.6%194
5
Ergocalciferol6.5%191
6
Bisoprolol-fumarate5.9%173
7
Atorvastatin-calcium5.6%163
8
Omeprazole5.4%159
9
Pantoprazole-sodium5.3%155
10
Metoprolol5.3%154
11
Ramipril5.1%149
12
Lansoprazole5.0%147
13
Albuterol4.9%144
14
Rosuvastatin4.9%143
15
Metformin4.7%137

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports bempedoic side effects

49.7% of bempedoic adverse event reports involve female patients and 32.8% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.7%
Male32.8%
Unknown17.6%

Age group

< 20.0%
2–110.1%
12–170.0%
18–6438.9%
65+61.0%

What is bempedoic used for

Conditions and purposes for which patients were taking bempedoic when the adverse event was reported.

ArteriosclerosisAcute Myocardial InfarctionAdjuvant TherapyAdverse Drug ReactionApolipoprotein AbnormalArteriosclerosisArteriosclerosis Coronary ArteryBlood CholesterolBlood Cholesterol AbnormalBlood Cholesterol DecreasedBlood Cholesterol IncreasedBlood Pressure MeasurementBlood Triglycerides IncreasedBlood Calcium IncreasedBlood Cholesterol

Showing 15 of 90 indications

Bempedoic brand names and reporting trend

Bempedoic is sold under brand names including Nexlizet, Bempedoic Acid And Ezetimibe.

Brand names

Nexlizet1,605
Bempedoic Acid And Ezetimibe240

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking bempedoic with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.