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Belzutifan Side Effects

The most commonly reported side effects of belzutifan include anaemia, hypoxia, and fatigue, based on 1,144 FDA adverse event reports from 2021 to 2025.

Belzutifan side effects

Percentages show how often each reaction appears relative to total reports for belzutifan.

1
Anaemia15.6%179
2
Hypoxia8.9%102
3
Fatigue8.4%96
4
Malignant Neoplasm Progression6.5%74
5
Death4.5%51
6
Diarrhoea4.2%48
7
Off Label Use3.9%45
8
Dyspnoea3.8%44
9
Haemoglobin Decreased3.4%39
10
Oxygen Saturation Decreased2.8%32
11
Nausea2.7%31
12
Therapy Interrupted2.4%27
13
Product Dose Omission Issue2.4%27
14
No Adverse Event2.3%26
15
Headache2.2%25

These are voluntary reports and do not establish that belzutifan caused these reactions.

Report severity

71.2%Serious815 reports
51.2%Hospitalizations586 reports
8.6%Fatal98 reports

Seriousness is determined by the reporter, not by OpenClaim.

Belzutifan drug interactions

Other drugs that appear in adverse event reports alongside belzutifan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenvatinib-mesylate42.6%487
2
Pembrolizumab28.1%322
3
Cabozantinib6.0%69
4
Tivozanib-hydrochloride1.1%13
5
Darbepoetin-alfa1.0%12
6
Esomeprazole0.7%8
7
Nivolumab0.6%7
8
Everolimus0.6%7
9
Axitinib0.6%7
10
Ipilimumab0.3%4
11
Epoetin0.3%4
12
Palbociclib0.3%3
13
Bevacizumab0.3%3
14
Amlodipine0.3%3
15
Acalabrutinib0.3%3

Taken alongside

1
Levothyroxine-sodium19.8%226
2
Acetaminophen17.5%200
3
Amlodipine14.0%160
4
Ondansetron9.3%106
5
Atorvastatin-calcium8.2%94
6
Oxycodone8.0%91
7
Omeprazole7.9%90
8
Losartan-potassium7.9%90
9
Pantoprazole-sodium7.9%90
10
Metformin7.4%85
11
Metoprolol6.3%72
12
Ergocalciferol6.1%70
13
Aspirin5.9%67
14
Prednisone5.5%63
15
Hydrochlorothiazide5.0%57

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports belzutifan side effects

37.2% of belzutifan adverse event reports involve female patients and 57.7% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female37.2%
Male57.7%
Unknown5.2%

Age group

< 20.0%
2–110.8%
12–171.2%
18–6457.7%
65+40.3%

What is belzutifan used for

Conditions and purposes for which patients were taking belzutifan when the adverse event was reported.

Acquired Gene MutationAdenocarcinoma PancreasAdverse Drug ReactionBile Duct AdenocarcinomaBile Duct CancerBone CancerBrain NeoplasmBrain Neoplasm MalignantBreast Cancer FemaleCarcinoid TumourCervix CarcinomaCholangiocarcinomaChronic Infantile Neurological Cutaneous And Articular SyndromeClear Cell Renal Cell CarcinomaColorectal Cancer

Showing 15 of 65 indications

Belzutifan brand names and reporting trend

Belzutifan is sold under the brand name Welireg.

Brand names

Welireg882

Quarterly reports (20212025)

2021202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking belzutifan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.