OpenClaim

Belumosudil Side Effects

The most commonly reported side effects of belumosudil include inappropriate schedule of product administration, product use in unapproved indication, and fatigue, based on 3,039 FDA adverse event reports from 2020 to 2025. 5.3% of reports found the drug to be ineffective.

Belumosudil side effects

Percentages show how often each reaction appears relative to total reports for belumosudil.

1
Inappropriate Schedule Of Product Administration13.2%401
2
Product Use In Unapproved Indication12.9%391
3
Fatigue8.9%269
4
Off Label Use6.6%200
5
Nausea5.4%164
6
Drug Ineffective5.3%162
7
Death5.3%160
8
Product Dose Omission Issue5.2%157
9
Condition Aggravated5.0%152
10
Pneumonia5.0%151
11
Diarrhoea4.8%147
12
Dyspnoea4.4%133
13
Hospitalisation4.2%127
14
Asthenia3.4%102
15
Cough3.2%98

These are voluntary reports and do not establish that belumosudil caused these reactions.

Report severity

53.0%Serious1,610 reports
27.2%Hospitalizations827 reports
9.5%Fatal288 reports

Seriousness is determined by the reporter, not by OpenClaim.

Belumosudil drug interactions

Other drugs that appear in adverse event reports alongside belumosudil. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ruxolitinib11.5%348
2
Prednisone3.0%90
3
Tacrolimus1.7%51
4
Sirolimus1.0%31
5
Ibrutinib0.9%26
6
Fluticasone0.7%21
7
Rituximab0.7%20
8
Methylprednisolone0.6%19
9
Mycophenolate0.5%16
10
Methotrexate0.5%15
11
Montelukast-sodium0.5%14
12
Azithromycin0.5%14
13
Axatilimab-csfr0.4%12
14
Posaconazole0.4%11
15
Abatacept0.4%11

Taken alongside

1
Acyclovir21.7%659
2
Prednisone17.3%525
3
Ergocalciferol13.7%415
4
Sulfamethoxazole12.2%372
5
Trimethoprim12.2%370
6
Tacrolimus10.1%307
7
Ruxolitinib9.1%277
8
Montelukast-sodium8.2%250
9
Posaconazole6.7%203
10
Fluticasone6.7%203
11
Pantoprazole-sodium6.4%195
12
Famotidine5.7%173
13
Ondansetron5.7%173
14
Gabapentin5.7%173
15
Omeprazole5.6%170

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports belumosudil side effects

38.8% of belumosudil adverse event reports involve female patients and 45.2% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.8%
Male45.2%
Unknown16.0%

Age group

< 20.2%
2–112.2%
12–174.3%
18–6460.5%
65+32.9%

What is belumosudil used for

Conditions and purposes for which patients were taking belumosudil when the adverse event was reported.

Acute Graft Versus Host DiseaseAcute Graft Versus Host Disease In SkinAcute LeukaemiaAcute Leukaemia In RemissionAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia (in Remission)Acute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia (in Remission)Acute Myelomonocytic LeukaemiaAcute Promyelocytic LeukaemiaAllogenic Stem Cell TransplantationAnaemiaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAngioimmunoblastic T-cell Lymphoma

Showing 15 of 98 indications

Belumosudil brand names and reporting trend

Belumosudil is sold under the brand name Rezurock.

Brand names

Rezurock978

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking belumosudil with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.