OpenClaim

Belantamab Side Effects

The most commonly reported side effects of belantamab include keratopathy, visual acuity reduced, and death, based on 2,653 FDA adverse event reports from 2012 to 2025. 3.4% of reports found the drug to be ineffective.

Belantamab side effects

Percentages show how often each reaction appears relative to total reports for belantamab.

1
Keratopathy31.3%830
2
Visual Acuity Reduced28.0%742
3
Death20.4%542
4
Plasma Cell Myeloma15.6%415
5
Dry Eye14.2%376
6
Night Blindness11.9%317
7
Photophobia7.1%189
8
Foreign Body Sensation In Eyes6.3%168
9
Vision Blurred5.7%151
10
Visual Impairment4.3%115
11
Ocular Toxicity4.2%112
12
Thrombocytopenia4.0%106
13
Punctate Keratitis3.9%104
14
Fatigue3.5%93
15
Corneal Epithelial Microcysts3.5%92

These are voluntary reports and do not establish that belantamab caused these reactions.

Report severity

88.7%Serious2,353 reports
25.9%Hospitalizations687 reports
35.2%Fatal934 reports

Seriousness is determined by the reporter, not by OpenClaim.

Belantamab drug interactions

Other drugs that appear in adverse event reports alongside belantamab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone18.4%487
2
Bortezomib12.0%319
3
Pomalidomide11.9%315
4
Lenalidomide6.6%176
5
Carfilzomib5.1%135
6
Cyclophosphamide4.7%126
7
Daratumumab3.8%102
8
Doxorubicin-hydrochloride2.8%73
9
Melphalan2.3%60
10
Ixazomib-citrate1.9%50
11
Etoposide1.8%47
12
Elotuzumab1.7%44
13
Thalidomide1.5%39
14
Cisplatin1.2%32
15
Bendamustine-hydrochloride1.2%31

Taken alongside

1
Acyclovir6.6%174
2
Dexamethasone5.8%154
3
Aspirin4.2%112
4
Bortezomib3.2%86
5
Pomalidomide3.2%84
6
Acetaminophen3.1%83
7
Carfilzomib2.8%73
8
Omeprazole2.5%65
9
Daratumumab2.3%62
10
Lenalidomide2.2%59
11
Pantoprazole-sodium2.1%57
12
Allopurinol2.1%57
13
Trimethoprim2.1%56
14
Cyclophosphamide2.0%53
15
Sulfamethoxazole2.0%53

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports belantamab side effects

21.0% of belantamab adverse event reports involve female patients and 28.7% involve male patients. The largest age group is elderly at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female21.0%
Male28.7%
Unknown50.3%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6436.0%
65+64.0%

What is belantamab used for

Conditions and purposes for which patients were taking belantamab when the adverse event was reported.

AmyloidosisAmyloidosisBlood Immunoglobulin A DecreasedBone LesionBreast CancerDiffuse Large B-cell LymphomaDisease ProgressionHaematological MalignancyLeukaemiaLight Chain DiseaseMonoclonal Antibody Chemoimmunoconjugate TherapyMalignant Neoplasm ProgressionMyelodysplastic SyndromeNeoplasmNeoplasm Malignant

Showing 15 of 29 indications

Belantamab brand names and reporting trend

Belantamab is sold under the brand name Blenrep.

Brand names

Blenrep3,184

Quarterly reports (20122025)

201220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking belantamab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.